Recombinant Human PGM1

• Cat.No.: PGM1-30003TH
• Product Overview: Recombinant full length Human PGM1 with a N terminal proprietary tag: predicted molecular weight 87.93 kDa inclusive of tag.

Specification

• Description: The protein encoded by this gene is an isozyme of phosphoglucomutase (PGM) and belongs to the phosphohexose mutase family. There are several PGM isozymes, which are encoded by different genes and catalyze the transfer of phosphate between the 1 and 6 positions of glucose. In most cell types, this PGM isozyme is predominant, representing about 90% of total PGM activity. In red cells, PGM2 is a major isozyme. This gene is highly polymorphic. Mutations in this gene cause glycogen storage disease type 14. Alternativley spliced transcript variants encoding different isoforms have been identified in this gene.
• Protein length: 562 amino acids
• Molecular Weight: 87.930kDa inclusive of tags
• Source: Wheat germ
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MVKIVTVKTQAYQDQKPGTSGLRKRVKVFQSSANYAENFI QSIISTVEPAQRQEATLVVGGDGRFYMKEAIQLIARIAAA NGIGRLVIGQNGILSTPAVSCIIRKIKAIGGIILTASHNP GGPNGDFGIKFNISNGGPAPEAITDKIFQISKTIEEYAVC PDLKVDLGVLGKQQFDLENKFKPFTVEIVDSVEAYATMLR SIFDFSALKELLSGPNRLKIRIDAMHGVVGPYVKKILCEE LGAPANSAVNCVPLEDFGGHHPDPNLTYAADLVETMKSGE HDFGAAFDGDGDRNMILGKHGFFVNPSDSVAVIAANIFSI PYFQQTGVRGFARSMPTSGALDRVASATKIALYETPTGWK FFGNLMDASKLSLCGEESFGTGSDHIREKDGLWAVLAWLS ILATRKQSVEDILKDHWQKYGRNFFTRYDYEEVEAEGANK MMKDLEALMFDRSFVGKQFSANDKVYTVEKADNFEYSDPV DGSISRNQGLRLIFTDGSRIVFRLSGTGSAGATIRLYIDS YEKDVAKINQDPQVMLAPLISIALKVSQLQERTGRTAPTV IT
• Sequence Similarities: Belongs to the phosphohexose mutase family.

Gene Information

• Gene Name: PGM1 phosphoglucomutase 1 [ Homo sapiens ]
• Official Symbol: PGM1
• Synonyms: PGM1; phosphoglucomutase 1; phosphoglucomutase-1
• Gene ID: 5236
• mRNA Refseq: NM_001172819
• Protein Refseq: NP_001166290
• MIM: 171900
• Uniprot ID: P36871
• Chromosome Location: 1p22.1
• Pathway: Amino sugar and nucleotide sugar metabolism, organism-specific biosystem; Amino sugar and nucleotide sugar metabolism, conserved biosystem; GDP-glucose biosynthesis, conserved biosystem; Galactose metabolism, organism-specific biosystem; Galactose metabolism, conserved biosystem
• Function: isomerase activity; magnesium ion binding; phosphoglucomutase activity