Recombinant Human PI4K2B

• Cat.No.: PI4K2B-30363TH
• Product Overview: Recombinant full length Human PI 4 Kinase type 2 beta with an N terminal proprietary tag; MWt 84 kDa.

Specification

• Description: Phosphatidylinositol 4-kinases (PI4Ks) phosphorylate phosphatidylinositol to generate phosphatidylinositol 4-phosphate (PIP), an immediate precursor of several important signaling and scaffolding molecules. PIP itself may also have direct functional and structural roles. PI4K2B is a primarily cytosolic PI4K that is recruited to membranes, where it stimulates phosphatidylinositol 4,5-bisphosphate synthesis (Wei et al.
• Protein length: 481 amino acids
• Molecular Weight: 84.000kDa inclusive of tags
• Source: Baculovirus infected sf9 cells
• Tissue specificity: Widely expressed.
• Biological activity: The Specific activity of PI4K2B-30363TH was determined to be 218 nmol/min/mg.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.Contains 1 PI3K/PI4K domain.

Gene Information

• Gene Name: PI4K2B phosphatidylinositol 4-kinase type 2 beta [ Homo sapiens ]
• Official Symbol: PI4K2B
• Synonyms: PI4K2B; phosphatidylinositol 4-kinase type 2 beta; phosphatidylinositol 4-kinase type 2-beta; FLJ11105; PI4KIIB; PIK42B
• Gene ID: 55300
• mRNA Refseq: NM_018323
• Protein Refseq: NP_060793
• MIM: 612101
• Uniprot ID: Q8TCG2
• Chromosome Location: 4p15.31
• Pathway: 3-phosphoinositide biosynthesis, conserved biosystem; D-myo-inositol (1,4,5)-trisphosphate biosynthesis, conserved biosystem; Inositol phosphate metabolism, organism-specific biosystem; Inositol phosphate metabolism, conserved biosystem; Inositol phosphate metabolism, PI=>
• Function: 1-phosphatidylinositol 4-kinase activity; ATP binding; kinase activity; nucleotide binding; transferase activity