Recombinant Human PLIN3, His-tagged

• Cat.No.: PLIN3-28660TH
• Product Overview: Recombinant full length protein, corresponding to amino acids 1-434 of Human M6PRBP1 with a His-Tag at N-terminus.

Specification

• Description: Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene.
• Conjugation: HIS
• Source: E. coli
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: 0.002% Sodium AzideConstituents: 3mM Sodium chloride, 10mM Tris, 2.5mM Imidazole, pH 8.0
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the perilipin family.

Gene Information

• Gene Name: PLIN3 perilipin 3 [ Homo sapiens ]
• Official Symbol: PLIN3
• Synonyms: PLIN3; perilipin 3; M6PRBP1, mannose 6 phosphate receptor binding protein 1; perilipin-3; cargo selection protein (mannose 6 phosphate receptor binding protein); MPR BINDING PROTEIN; 47 KD; placental protein 17; PP17; TIP47
• Gene ID: 10226
• mRNA Refseq: NM_001164189
• Protein Refseq: NP_001157661
• MIM: 602702
• Uniprot ID: O60664
• Chromosome Location: 19p13.3
• Function: protein binding