Recombinant Human POLD2

• Cat.No.: POLD2-28358TH
• Product Overview: Recombinant full length Human DNA polymerase delta p50 with a N terminal proprietary tag; predicted MW: 77.66 kDa, inclusive of tag. P49005,

Specification

• Description: The DNA polymerase delta complex is involved in DNA replication and repair, and it consists of the proliferating cell nuclear antigen (PCNA; MIM 176740), the multisubunit replication factor C (see MIM 102579), and the 4 subunit polymerase complex: POLD1 (MIM 174761), POLD2, POLD3 (MIM 611415), and POLD4 (MIM 611525) (Liu and Warbrick, 2006
• Protein length: 469 amino acids
• Molecular Weight: 77.660kDa inclusive of tags
• Source: Wheat germ
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MFSEQAAQRAHTLLSPPSANNATFARVPVATYTNSSQPFR LGERSFSRQYAHIYATRLIQMRPFLENRAQQHWGSGVGVK KLCELQPEEKCCVVGTLFKAMPLQPSILREVSEEHNLLPQ PPRSKYIHPDDELVLEDELQRIKLKGTIDVSKLVTGTVLA VFGSVRDDGKFLVEDYCFADLAPQKPAPPLDTDRFVLLVS GLGLGGGGGESLLGTQLLVDVVTGQLGDEGEQCSAAHVSR VILAGNLLSHSTQSRDSINKAKYLTKKTQAASVEAVKMLD EILLQLSASVPVDVMPGEFDPTNYTLPQQPLHPCMFPLAT AYSTLQLVTNPYQATIDGVRFLGTSGQNVSDIFRYSSMED HLEILEWTLRVRHISPTAPDTLGCYPFYKTDPFIFPECPH VYFCGNTPSFGSKIIRGPEDQTVLLVTVPDFSATQTACLV NLRSLACQPISFSGFGAEDDDLGGLGLGP
• Sequence Similarities: Belongs to the DNA polymerase delta/II small subunit family.

Gene Information

• Gene Name: POLD2 polymerase (DNA directed), delta 2, regulatory subunit 50kDa [ Homo sapiens ]
• Official Symbol: POLD2
• Synonyms: POLD2; polymerase (DNA directed), delta 2, regulatory subunit 50kDa; polymerase (DNA directed), delta 2, regulatory subunit (50kD); DNA polymerase delta subunit 2
• Gene ID: 5425
• mRNA Refseq: NM_001127218
• Protein Refseq: NP_001120690
• MIM: 600815
• Uniprot ID: P49005
• Chromosome Location: 7
• Pathway: Base Excision Repair, organism-specific biosystem; Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Chromosome Maintenance, organism-specific biosystem
• Function: DNA binding; DNA-directed DNA polymerase activity; nucleotidyltransferase activity; protein binding; transferase activity