Recombinant Human POLR2I

• Cat.No.: POLR2I-30766TH
• Product Overview: Recombinant full length human RNA Polymerase II p14.5 with proprietary tag; amino acids 1-125, approximately 41kDa.

Specification

• Description: This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with two other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. The product of this gene has two zinc finger motifs with conserved cysteines and the subunit does possess zinc binding activity.
• Source: E. coli
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 20mM Tris Cl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.

Gene Information

• Gene Name: POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa [ Homo sapiens ]
• Official Symbol: POLR2I
• Synonyms: POLR2I; polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa; polymerase (RNA) II (DNA directed) polypeptide I (14.5kD); DNA-directed RNA polymerase II subunit RPB9; hRPB14.5; RPB9
• Gene ID: 5438
• mRNA Refseq: NM_006233
• Protein Refseq: NP_006224
• MIM: 180662
• Uniprot ID: P36954
• Chromosome Location: 19q12
• Pathway: Abortive elongation of HIV-1 transcript in the absence of Tat, organism-specific biosystem; DNA Repair, organism-specific biosystem; Dual incision reaction in TC-NER, organism-specific biosystem; Eukaryotic Transcription Initiation, organism-specific biosystem; Formation and Maturation of mRNA Transcript, organism-specific biosystem
• Function: DNA binding; DNA-directed RNA polymerase activity; metal ion binding; contributes_to protein kinase activity; zinc ion binding