Recombinant Human Cathepsin F, His-tagged

• Cat.No.: CTSF-506H
• Product Overview: Recombinant Human cathepsin F, CD33 signal peptide(1-16aa) + cathepsin S (a-a 20-end), with C-terminal His tag expressed inFreeStyle 293-F cells. MW= 53 kDa.

Specification

• Cat. No.: CTSF-506H
• Description: Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide.
• Source: FreeStyle 293-F cells.
• Purity: >90%.
• Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
• Formulated In: 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20 and 10% glycerol.
• Stability: >6 months at –80°C.
• nullValue_other: Lysosome

Gene Information

• Gene Name: CTSF cathepsin F [ Homo sapiens ]
• Synonyms: CTSF; cathepsin F; CATSF;Cathepsin F;EC3.4.22.41
• Gene ID: 8722
• mRNA Refseq: NM_003793
• Protein Refseq: NP_003784
• MIM: 603539
• UniProt ID: Q9UBX1
• Chromosome Location: 11q13
• Function: cysteine-type endopeptidase activity; peptidase activity