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Recombinant Human Cathepsin F, His-tagged

Cat. No.: CTSF-506H
Product Overview: Recombinant Human cathepsin F, CD33 signal peptide(1-16aa) + cathepsin S (a-a 20-end), with C-terminal His tag expressed inFreeStyle 293-F cells. MW= 53 kDa.
Description: Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide.
Source: FreeStyle 293-F cells.
Purity: >90%.
Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Formulated In: 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20 and 10% glycerol.
Stability: >6 months at –80°C.
nullValue_other: Lysosome
Gene Name: CTSF cathepsin F [ Homo sapiens ]
Synonyms: CTSF; cathepsin F; CATSF;Cathepsin F;EC3.4.22.41
Gene ID: 8722
mRNA Refseq: NM_003793
Protein Refseq: NP_003784
MIM: 603539
UniProt ID: Q9UBX1
Chromosome Location: 11q13
Function: cysteine-type endopeptidase activity; peptidase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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