Recombinant Human Cathepsin F, His-tagged

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Recombinant Human Cathepsin F, His-tagged

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Cat. No. : CTSF-506H
Product Overview : Recombinant Human cathepsin F, CD33 signal peptide(1-16aa) + cathepsin S (a-a 20-end), with C-terminal His tag expressed inFreeStyle 293-F cells. MW= 53 kDa.
Description : Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide.
Source : FreeStyle 293-F cells.
Purity : >90%.
Application : Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Formulated In : 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20 and 10% glycerol.
Stability : >6 months at –80°C.
nullValue_other : Lysosome
PDB rendering based on 1m6d. :

Gene Name : CTSF cathepsin F [ Homo sapiens ]
Synonyms : CTSF; cathepsin F; CATSF;Cathepsin F;EC3.4.22.41
Gene ID : 8722
mRNA Refseq : NM_003793
Protein Refseq : NP_003784
MIM : 603539
UniProt ID : Q9UBX1
Chromosome Location : 11q13
Function : cysteine-type endopeptidase activity; peptidase activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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