"PON2" Related Products


Recombinant Human PON2, His-tagged

Cat.No.: PON2-30704TH
Product Overview: Recombinant full length PON2 protein (Human) with an amino-terminal hexahistidine tag.
Description: This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described.
Conjugation: HIS
Source: E. coli
Tissue specificity: Widely expressed with highest expression in liver, lung, placenta, testis and heart.
Form: Liquid
Purity: >95% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 50% Glycerol, 20mM Tris, pH 8
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequence Similarities: Belongs to the paraoxonase family.
Gene Name: PON2 paraoxonase 2 [ Homo sapiens ]
Official Symbol: PON2
Synonyms: PON2; paraoxonase 2; serum paraoxonase/arylesterase 2; paraoxonase nirs;
Gene ID: 5445
mRNA Refseq: NM_000305
Protein Refseq: NP_000296
MIM: 602447
Uniprot ID: Q15165
Chromosome Location: 7q21.3
Pathway: Metabolic pathways, organism-specific biosystem;
Function: arylesterase activity; hydrolase activity; identical protein binding; metal ion binding;

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