Recombinant Human PPARG, His-tagged
Cat.No. : | PPARG-31034TH |
Product Overview : | Recombinant fragment, corresponding to amino acids 204-477 of His tagged Human PPAR gamma. Predicted MW 31 kDa, |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. |
Conjugation : | HIS |
Source : | E. coli |
Tissue specificity : | Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary. |
Biological activity : | PPARG-31034TH has been tested in a SRC1 interaction assay and has been found to be ligand dependent. |
Form : | Liquid |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 20% Glycerol, 20mM Tris HCl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0 |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the nuclear hormone receptor family. NR1 subfamily.Contains 1 nuclear receptor DNA-binding domain. |
Gene Name : | PPARG peroxisome proliferator-activated receptor gamma [ Homo sapiens ] |
Official Symbol : | PPARG |
Synonyms : | PPARG; peroxisome proliferator-activated receptor gamma; peroxisome proliferative activated receptor, gamma; NR1C3; PPARG1; PPARG2; PPARgamma; |
Gene ID : | 5468 |
mRNA Refseq : | NM_005037 |
Protein Refseq : | NP_005028 |
MIM : | 601487 |
Uniprot ID : | P37231 |
Chromosome Location : | 3p25 |
Pathway : | Adipogenesis, organism-specific biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Energy Metabolism, organism-specific biosystem; Gene Expression, organism-specific biosystem; |
Function : | DNA binding; activating transcription factor binding; arachidonic acid binding; drug binding; enzyme binding; |
Products Types
◆ Recombinant Protein | ||
Pparg-5030M | Recombinant Mouse Pparg Protein, Myc/DDK-tagged | +Inquiry |
PPARG-3355R | Recombinant Rhesus Macaque PPARG Protein, His (Fc)-Avi-tagged | +Inquiry |
Pparg-1961M | Recombinant Mouse Pparg Protein, His-tagged | +Inquiry |
PPARG-4935H | Recombinant Human PPARG Protein, His-tagged | +Inquiry |
PPARG-0778H | Recombinant Human PPARG Protein (P234-Y505), His tagged | +Inquiry |
◆ Lysates | ||
PPARG-492HCL | Recombinant Human PPARG cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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