Recombinant Human PPHLN1, His-tagged

• Cat.No.: PPHLN1-28673TH
• Product Overview: Recombinant fragment, corresponding to amino acids 68-293 of Human PPHLN1 isoform 8, with N terminal His tag; 226 amino acids, 33kDa (26kDa predicted from sequence). Gene ID = 51535

Specification

• Description: The protein encoded by this gene is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis. This protein interacts with periplakin, which is known as a precursor of the cornified cell envelope. The cellular localization pattern and insolubility of this protein suggest that it may play a role in epithelial differentiation and contribute to epidermal integrity and barrier formation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Ubiquitous.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: YKRDNTFFRESPVGRKDSPHSRSGS SVSSRSYSPERSKSY SFHQSQHRNKERPVQSLKTSRDTSP SSGSAVSSSKVLD KPSRLTEKELAEAASKWAAEKLEKS DESNLPEISEYEA GSTAPLFTDQPEEPESNTTHGIELF EDSQLTTRSKAIA SKTKEIEQVYRQDCETFGMVVKMLI EKDPSLEKSIQFALRQNLHEIGERC VEELKHFIAEYDTSTQDFGEPF

Gene Information

• Gene Name: PPHLN1 periphilin 1 [ Homo sapiens ]
• Official Symbol: PPHLN1
• Synonyms: PPHLN1; periphilin 1; periphilin-1
• Gene ID: 51535
• mRNA Refseq: NM_201515
• Protein Refseq: NP_958923
• MIM: 608150
• Uniprot ID: Q8NEY8
• Chromosome Location: 12q12