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Active Recombinant Human PPIA

Cat.No. : PPIA-26334TH
Product Overview : Recombinant human PPIA, was expressed in E.coli and purified by using conventional chromatography techniques.
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Description : This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported.
Source : E.coli
Species : Human
Form : In 20mM Tris pH 8.0, .20mM NaCl, 0.5mM DTT, 10% glycerol
Bio-activity : Specific activity is > 270 nmoles/min/mg, and is defined as the amount of enzyme that cleaves 1umole of suc-AAFP-pNA per minute at 25C in Tris-Hcl pH8.0 using chymotrypsin.
Molecular Mass : 20kDa (185aa), confirmed by MALDI-TOF.
Protein length : 1-165 aa
AA Sequence : MGSSHHHHHH SSGLVPRGSH MVNPTVFFDI AVDGEPLGRV SFELFADKVP KTAENFRALS TGEKGFGYKG SCFHRIIPGF MCQGGDFTRH NGTGGKSIYG EKFEDENFIL KHTGPGILSM ANAGPNTNGS QFFICTAKTE WLDGKHVVFG KVKEGMNIVE AMERFGSRNG KTSKKITIAD CGQLE
Endotoxin : < 1.0 EU per 1 microgram of protein (determined by LAL method)
Purity : > 95% by SDS - PAGE
Applications : SDS-PAGE
Storage : Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Concentration : 1 mg/ml (determined by Bradford assay)
Publication :
The Cyclophilin A-CD147 complex promotes the proliferation and homing of multiple myeloma cells. (2015)
Induction of CIITA by IFN-γ in macrophages involves STAT1 activation by JAK and JNK (2021)
Gene Name : PPIA peptidylprolyl isomerase A (cyclophilin A) [ Homo sapiens ]
Official Symbol : PPIA
Synonyms : PPIA; peptidylprolyl isomerase A (cyclophilin A); peptidyl-prolyl cis-trans isomerase A; CYPA; CYPH; HEL-S-69p; PPIase A; rotamase A; cyclophilin; T cell cyclophilin; cyclosporin A-binding protein; epididymis secretory sperm binding protein Li 69p; NP_066953.1; EC 5.2.1.8
Gene ID : 5478
mRNA Refseq : NM_021130
Protein Refseq : NP_066953
MIM : 123840
UniProt ID : P62937
Chromosome Location : 7p13
Pathway : APOBEC3G mediated resistance to HIV-1 infection; Assembly Of The HIV Virion; Basigin interactions
Function : peptide binding; peptidyl-prolyl cis-trans isomerase activity; poly(A) RNA binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can PPIA be used as a therapeutic target for infectious diseases? 10/17/2022

PPIA has been studied in the context of infectious diseases, particularly in viral infections, as a potential therapeutic target.

Are there any side effects associated with drugs that target PPIA? 07/07/2022

Some drugs targeting PPIA may have side effects, including immunosuppression, which needs to be carefully managed.

Is PPIA used in organ transplantation procedures? 07/04/2021

Yes, PPIA has been studied in the context of organ transplantation due to its role in immune responses and immunosuppression.

Can PPIA be used as a potential drug target for neuroprotective therapies? 04/09/2019

PPIA modulation has shown promise in neuroprotection, making it a potential drug target for neurodegenerative disorders.

Are there any drugs that target PPIA for clinical use? 05/11/2017

Some drugs, such as cyclosporine, target PPIA for immunosuppressive purposes in transplantation and autoimmune diseases.

Customer Reviews (3)

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Reviews
03/04/2022

    The PPIA protein's robustness and stability have contributed significantly to the success of my experiments, enabling precise and reproducible measurements.

    05/31/2020

      I highly recommend the PPIA protein for a wide range of research applications.

      06/16/2019

        Its exceptional performance, in combination with its clear and distinct protein bands, make it an absolute must-have for researchers looking to achieve accurate and reliable results in their experiments.

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