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Recombinant Human PRKCQ

Cat.No. : PRKCQ-30178TH
Product Overview : Recombinant full length Human PKC theta with an N terminal enzyme tag.Expressed by Baculovirus in Sf9 insect cells.
Description : Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors.
Tissue specificity : Skeletal muscle, megakaryoblastic cells and platelets.
Biological activity : Specific activity: 792 nmol/min/mg
Form : Liquid
Storage buffer : Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.Contains 1 AGC-kinase C-terminal domain.Contains 1 C2 domain.Contains 2 phorbol-ester/DAG-type zinc fingers.Contains 1 protein kinase domain.
Gene Name : PRKCQ protein kinase C, theta [ Homo sapiens ]
Official Symbol : PRKCQ
Synonyms : PRKCQ; protein kinase C, theta; protein kinase C theta type;
Gene ID : 5588
mRNA Refseq : NM_001242413
Protein Refseq : NP_001229342
MIM : 600448
Uniprot ID : Q04759
Chromosome Location : 10p15
Pathway : Adaptive Immune System, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem;
Function : ATP binding; metal ion binding; nucleotide binding; protein binding; protein kinase C activity;

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