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Recombinant Human PRKCQ

Cat.No. : PRKCQ-30178TH
Product Overview : Recombinant full length Human PKC theta with an N terminal enzyme tag.Expressed by Baculovirus in Sf9 insect cells.
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Description : Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors.
Tissue specificity : Skeletal muscle, megakaryoblastic cells and platelets.
Biological activity : Specific activity: 792 nmol/min/mg
Form : Liquid
Storage buffer : Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.Contains 1 AGC-kinase C-terminal domain.Contains 1 C2 domain.Contains 2 phorbol-ester/DAG-type zinc fingers.Contains 1 protein kinase domain.
Gene Name : PRKCQ protein kinase C, theta [ Homo sapiens ]
Official Symbol : PRKCQ
Synonyms : PRKCQ; protein kinase C, theta; protein kinase C theta type;
Gene ID : 5588
mRNA Refseq : NM_001242413
Protein Refseq : NP_001229342
MIM : 600448
Uniprot ID : Q04759
Chromosome Location : 10p15
Pathway : Adaptive Immune System, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem;
Function : ATP binding; metal ion binding; nucleotide binding; protein binding; protein kinase C activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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