||Recombinant fragment, corresponding to amino acids 230-609 of Human RASGRP2 with an N terminal His tag. Observed mwt: 50 kDa ;
||The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Three alternatively spliced transcript variants encoding the same protein have been found for this gene.
||Lyophilised:Reconstitute with 124 μl aqua dest.
||Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
||Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
|Sequences of amino acids:
||VAEKLLQLQNFNTLMAVVGGLSHSSISRLKETHSHVSPET IKLWEGLTELVTATGNYGNYRRRLAACVGFRFPILGVH LKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLSLLTVSLDQYQTEDELYQLSLQRE PRSKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQALV VEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSA FGDLDQNQDGCISREEMVSYFLRSSSVLGGRMGFVHNF QESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQ CKDRLSVECRRRAQSVSLEGSAPSPSPMHSHHHRAFSFSL PRPGRRGSRPPEIREEEVQTVEDGVFDIHL