||Recombinant fragment, corresponding to amino acids 188-390 of Human NORE1, containing the Ras Association Domain, with a proprietary tag; MWt 47 kDa with tag.
||This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene.
||Widely expressed. Frequently down-regulated in lung tumor cell lines and primary lung tumors.
||>90% by SDS-PAGE
||Preservative: NoneConstituents: PBS, 1mM EDTA
||Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
||Contains 1 phorbol-ester/DAG-type zinc finger.Contains 1 Ras-associating domain.Contains 1 SARAH domain.