||Recombinant fragment, corresponding to amino acids 94-485 of Human RBPJK Isoform 4 with an N terminal His tag; Predicted MWt 45 kDa.
||The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Also, this protein can bind specifically to the recombination signal sequence of immunglobulin kappa type J segments. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9.
||Lyophilised:Reconstitute with 72 μl aqua dest.
||Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
||Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
|Sequences of amino acids:
||DQEMQQLNLEGKNYCTAKTLYISDSDKRKHFMLSVKMFYG NSDDIGVFLSKRIKVISKPSKKKQSLKNADLCIASGTK VALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFFIHL LDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRL IIRKVDKQTALLDADDPVSQLHKCAFYLKDTERMYLCLSQ ERIIQFQATPCPKEPNKEMINDGASWTIISTDKAEYTF YEGMGPVLAPVTPVPVVESLQLNGGGDVAMLELTGQNF TPNLRVWFGDVEAETMYRCGESMLCVVPDISAFREGWR WVRQPVQVPVTLVRNDGIIYSTSLTFTYTPEPGPRPHC SAAGAILRANSSQVPPNESNTNSEGSYTNASTNSTSVTSS TATVVS
||Belongs to the Su(H) family.Contains 1 IPT/TIG domain.