Recombinant Human RHOB

• Cat.No.: RHOB-30284TH
• Product Overview: Recombinant full length Human RHOB protein; amino acids 1-196, Predicted MWt 22kDa.

Specification

• Description: Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation.
• Source: E. coli
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 40mM Sodium chloride, 25mM HEPES, 2mM DTT, 2mM Magnesium chloride, 0.01mM GDP, pH 7.2
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the small GTPase superfamily. Rho family.

Gene Information

• Gene Name: RHOB ras homolog gene family, member B [ Homo sapiens ]
• Official Symbol: RHOB
• Synonyms: RHOB; ras homolog gene family, member B; ARH6, ARHB; rho-related GTP-binding protein RhoB; MST081; oncogene RHO H6; RhoB; RHOH6
• Gene ID: 388
• mRNA Refseq: NM_004040
• Protein Refseq: NP_004031
• MIM: 165370
• Uniprot ID: P62745
• Chromosome Location: 2p24
• Pathway: Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Focal Adhesion, organism-specific biosystem; G alpha (12/13) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem
• Function: GDP binding; GTP binding; GTPase activity; nucleotide binding; protein binding