Recombinant Human SEPT6, HIS-tagged

• Cat.No.: SEPT6-30968TH
• Product Overview: Recombinant full length Human SEPT6 with a N terminal His tag; 457 amino acids with the tag; predicted MWt of 52.1 kDa.

Specification

• Description: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined.
• Protein length: 434 amino acids
• Conjugation: HIS
• Molecular Weight: 52.100kDa inclusive of tags
• Source: E. coli
• Tissue specificity: Widely expressed.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: pH: 8.00Constituents:0.32% Tris HCl, 0.03% DTT, 10% Glycerol, 0.58% Sodium chloride
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMGSMA ATDIARQVGEGCRTVPLAGHVGFDS LPDQLVNKSVSQGFCFNILCVGETG LGKSTLMDTLFNTKFEGEPATHTQP GVQLQSNTYDLQESNVRLKLTIVST VGFGDQINKEDSYKPIVEFIDAQFE AYLQEELKIRRVLHTYHDSRIHVCL YFIAPTGHSLKSLDLVTMKKLDSKV NIIPIIAKADAISKSELTKFKIKIT SELVSNGVQIYQFPTDDESVAEING TMNAHLPFAVIGSTEELKIGNKMMR ARQYPWGTVQVENEAHCDFVKLREM LIRVNMEDLREQTHTRHYELYRRCK LEEMGFKDTDPDSKPFSLQETYEAK RNEFLGELQKKEEEMRQMFVQRVKE KEAELKEAEKELHEKFDRLKKLHQD EKKKLEDKKKSLDDEVNAFKQRKTA AELPQSQGSQAGGSQTLKRDKEKKN NPWLCTE
• Sequence Similarities: Belongs to the septin family.

Gene Information

• Gene Name: SEPT6 septin 6 [ Homo sapiens ]
• Official Symbol: SEPT6
• Synonyms: SEPT6; septin 6; septin-6; KIAA0128; MGC16619; MGC20339; SEP2; SEPT2
• Gene ID: 23157
• mRNA Refseq: NM_015129
• Protein Refseq: NP_055944
• MIM: 300683
• Uniprot ID: Q14141
• Chromosome Location: Xq24
• Function: GTP binding; nucleotide binding; protein binding