Recombinant Human SH2D1A, His-tagged
Cat.No. : | SH2D1A-31018TH |
Product Overview : | Recombinant full-length human SH2D1A/SAP , with N termianl His tag, 148aa, 16.3kDa inclusive of tag. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. |
Protein length : | 128 amino acids |
Conjugation : | HIS |
Molecular Weight : | 16.300kDa inclusive of tags |
Source : | E. coli |
Form : | Liquid |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 7.5 |
Storage : | Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
Sequences of amino acids : | MGSSHHHHHH SSGLVPRGSH MDAVAVYHGK ISRETGEKLL LATGLDGSYL LRDSESVPGV YCLCVLYHGY IYTYRVSQTE TGSWSAETAP GVHKRYFRKI KNLISAFQKP DQGIVIPLQY PVEKKSSARS TQGTTGIRED PDVCLKAP |
Gene Name : | SH2D1A SH2 domain containing 1A [ Homo sapiens ] |
Official Symbol : | SH2D1A |
Synonyms : | SH2D1A; SH2 domain containing 1A; IMD5, lymphoproliferative syndrome , LYP, SH2 domain protein 1A; SH2 domain-containing protein 1A; DSHP; Duncans disease; EBVS; MTCP1; SAP; XLP; XLPD; |
Gene ID : | 4068 |
mRNA Refseq : | NM_002351 |
Protein Refseq : | NP_002342 |
MIM : | 300490 |
Uniprot ID : | O60880 |
Chromosome Location : | Xq25 |
Pathway : | Direct p53 effectors, organism-specific biosystem; Measles, organism-specific biosystem; Measles, conserved biosystem; Natural killer cell mediated cytotoxicity, organism-specific biosystem; Natural killer cell mediated cytotoxicity, conserved biosystem; |
Function : | SH3/SH2 adaptor activity; |
Products Types
◆ Recombinant Protein | ||
Sh2d1a-5834M | Recombinant Mouse Sh2d1a Protein, Myc/DDK-tagged | +Inquiry |
SH2D1A-8116M | Recombinant Mouse SH2D1A Protein, His (Fc)-Avi-tagged | +Inquiry |
SH2D1A-5033R | Recombinant Rat SH2D1A Protein, His (Fc)-Avi-tagged | +Inquiry |
SH2D1A-22H | Recombinant Human SH2D1A Protein, MYC/DDK-tagged | +Inquiry |
SH2D1A-4001R | Recombinant Rhesus Macaque SH2D1A Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
SH2D1A-1879HCL | Recombinant Human SH2D1A 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket