"SHMT2" Related Products

Recombinant Human SHMT2, His-tagged

Cat.No.: SHMT2-31356TH
Product Overview: Recombinant fragment, corresponding to amino acids 376-504 of Human SHMT2 with an N terminal His tag; Predicted MWt 15 kDa.
Description: This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants.
Conjugation: HIS
Source: E. coli
Form: Lyophilised:Reconstitute with 125 μl aqua dest.
Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Gene Name: SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) [ Homo sapiens ]
Official Symbol: SHMT2
Synonyms: SHMT2; serine hydroxymethyltransferase 2 (mitochondrial); SHMT; serine hydroxymethyltransferase, mitochondrial;
Gene ID: 6472
mRNA Refseq: NM_001166356
Protein Refseq: NP_001159828
MIM: 138450
Uniprot ID: P34897
Chromosome Location: 12q12-q14
Pathway: C1-unit interconversion, eukaryotes, organism-specific biosystem; C1-unit interconversion, eukaryotes, conserved biosystem; Cyanoamino acid metabolism, organism-specific biosystem; Cyanoamino acid metabolism, conserved biosystem; Glycine, serine and threonine metabolism, organism-specific biosystem;
Function: L-allo-threonine aldolase activity; amino acid binding; chromatin binding; glycine hydroxymethyltransferase activity; glycine hydroxymethyltransferase activity;

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