Native Human SNCA
Cat.No. : | SNCA-27342TH |
Product Overview : | SNCA-27342TH is a deletion mutant of human alpha synuclein , which contains the N terminal amphipathic domain. |
- Specification
- Gene Information
- Related Products
Description : | Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimers disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. |
Source : | E. coli |
Tissue specificity : | Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals. |
Form : | Liquid |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 20mM Tris HCl, 100mM Sodium chloride, pH 7.5 |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
Sequences of amino acids : | MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK |
Sequence Similarities : | Belongs to the synuclein family. |
Gene Name : | SNCA synuclein, alpha (non A4 component of amyloid precursor) [ Homo sapiens ] |
Official Symbol : | SNCA |
Synonyms : | SNCA; synuclein, alpha (non A4 component of amyloid precursor); PARK1, PARK4, Parkinson disease (autosomal dominant, Lewy body) 4; alpha-synuclein; alpha synuclein; NACP; PD1; |
Gene ID : | 6622 |
mRNA Refseq : | NM_000345 |
Protein Refseq : | NP_000336 |
MIM : | 163890 |
Uniprot ID : | P37840 |
Chromosome Location : | 4q21.3-q22 |
Pathway : | Alpha-synuclein signaling, organism-specific biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Amyloids, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; |
Function : | Hsp70 protein binding; alpha-tubulin binding; arachidonic acid binding; calcium ion binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; |
Products Types
◆ Recombinant Protein | ||
SNCA-02H | Recombinant Human SNCA Protein | +Inquiry |
SNCA-8524M | Recombinant Mouse SNCA Protein, His (Fc)-Avi-tagged | +Inquiry |
SNCA-2710H | Recombinant Human SNCA Protein, His-tagged | +Inquiry |
SNCA-2058H | Recombinant Human SNCA Protein, MYC/DDK-tagged | +Inquiry |
Snca-1372R | Recombinant Rat Snca Protein, GST-tagged | +Inquiry |
◆ Native Protein | ||
SNCA-27341TH | Native Human SNCA | +Inquiry |
SNCA-27345TH | Native Human SNCA | +Inquiry |
SNCA-27339TH | Native Human SNCA | +Inquiry |
◆ Lysates | ||
SNCA-1634HCL | Recombinant Human SNCA 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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