Recombinant Human SNX1, His-tagged

• Cat.No.: SNX1-30609TH
• Product Overview: Recombinant fragment corresponding to amino acids 146-522 of Human SNX1 with an N terminal His tag; 415 amino acids with tag, Predicted MWt 48 kDa.

Specification

• Description: This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms.
• Protein length: 377 amino acids
• Conjugation: HIS
• Molecular Weight: 48.000kDa inclusive of tags
• Source: E. coli
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MRGSHHHHHHGMASMTGGQQMGRDL YDDDDKDRWGGSMTVGITDPEKIGD GMNAYVAYKVTTQTSLPLFRSKQFA VKRRFSDFLGLYEKLSEKHSQNGFI VPPPPEKSLIGMTKVKVGKEDSSSA EFLEKRRAALERYLQRIVNHPTMLQ DPDVREFLEKEELPRAVGTQTLSGA GLLKMFNKATDAVSKMTIKMNESDI WFEEKLQEVECEEQRLRKLHAVVET LVNHRKELALNTAQFAKSLAMLGSS EDNTALSRALSQLAEVEEKIEQLHQ EQANNDFFLLAELLSDYIRLLAIVR AAFDQRMKTWQRWQDAQATLQKKRE AEARLLWANKPDKLQQAKDEILEWE SRVTQYERDFERISTVVRKEVIRFE KEKSKDFKNHVIKYLETLLYSQQQL AKYWEAFLPEAKAIS
• Sequence Similarities: Belongs to the sorting nexin family.Contains 1 BAR domain.Contains 1 PX (phox homology) domain.

Gene Information

• Gene Name: SNX1 sorting nexin 1 [ Homo sapiens ]
• Official Symbol: SNX1
• Synonyms: SNX1; sorting nexin 1; sorting nexin-1; HsT17379; MGC8664; SNX1A; Vps5
• Gene ID: 6642
• mRNA Refseq: NM_001242933
• Protein Refseq: NP_001229862
• MIM: 601272
• Uniprot ID: Q13596
• Chromosome Location: 15q22.31
• Pathway: TGF-beta Receptor Signaling Pathway, organism-specific biosystem
• Function: lipid binding; phosphatidylinositol binding; protein binding; protein transporter activity