Recombinant Human SNX1, His-tagged SNX1-30609TH

Specification
Gene Information
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Cat.No.:	SNX1-30609TH
Product Overview:	Recombinant fragment corresponding to amino acids 146-522 of Human SNX1 with an N terminal His tag; 415 amino acids with tag, Predicted MWt 48 kDa.
Description:	This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms.
Protein length:	377 amino acids
Conjugation:	HIS
Molecular Weight:	48.000kDa inclusive of tags
Source:	E. coli
Form:	Liquid
Purity:	>90% by SDS-PAGE
Storage buffer:	Preservative: NoneConstituents: 10% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0
Storage:	Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids:	MRGSHHHHHHGMASMTGGQQMGRDLYDDDDKDRWGGSMTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDNTALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRWQDAQATLQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIRFEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS
Sequence Similarities:	Belongs to the sorting nexin family.Contains 1 BAR domain.Contains 1 PX (phox homology) domain.

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Gene Name:	SNX1 sorting nexin 1 [ Homo sapiens ]
Official Symbol:	SNX1
Synonyms:	SNX1; sorting nexin 1; sorting nexin-1; HsT17379; MGC8664; SNX1A; Vps5;
Gene ID:	6642
mRNA Refseq:	NM_001242933
Protein Refseq:	NP_001229862
MIM:	601272
Uniprot ID:	Q13596
Chromosome Location:	15q22.31
Pathway:	TGF-beta Receptor Signaling Pathway, organism-specific biosystem;
Function:	lipid binding; phosphatidylinositol binding; protein binding; protein transporter activity;