Recombinant Human SSB

• Cat.No.: SSB-29274TH
• Product Overview: Recombinant full length human SSB, 47.6kDa.

Specification

• Description: La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III (see MIM 606007)-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome (MIM 270150) and systemic lupus erythematosus (SLE; MIM 152700) (Teplova et al.
• Source: E. coli
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: 0.1% Sodium AzideConstituents: 150mM Sodium chloride, 10mM Sodium phosphate, pH 7.2
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Contains 1 HTH La-type RNA-binding domain.Contains 1 RRM (RNA recognition motif) domain.

Gene Information

• Gene Name: SSB Sjogren syndrome antigen B (autoantigen La) [ Homo sapiens ]
• Official Symbol: SSB
• Synonyms: SSB; Sjogren syndrome antigen B (autoantigen La); lupus La protein; La; La ribonucleoprotein domain family; member 3; LARP3
• Gene ID: 6741
• mRNA Refseq: NM_003142
• Protein Refseq: NP_003133
• MIM: 109090
• Uniprot ID: P05455
• Chromosome Location: 2q31.1
• Pathway: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription, organism-specific biosystem; RNA Polymerase III Abortive And Retractive Initiation, organism-specific biosystem; RNA Polymerase III Transcription, organism-specific biosystem; RNA Polymerase III Transcription Termination, organism-specific biosystem; Systemic lupus erythematosus, organism-specific biosystem
• Function: mRNA binding; nucleotide binding; tRNA binding