"STAT4" Related Products

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Recombinant Human STAT4

Cat.No.: STAT4-30118TH
Product Overview: Recombinant full length Human STAT4 protein expressed in a baculovirus system, Predicted MWt 86 kDa.
Description: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein.
Form: Liquid
Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 20mM Tris HCl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities: Belongs to the transcription factor STAT family.Contains 1 SH2 domain.
Gene Name: STAT4 signal transducer and activator of transcription 4 [ Homo sapiens ]
Official Symbol: STAT4
Synonyms: STAT4; signal transducer and activator of transcription 4;
Gene ID: 6775
mRNA Refseq: NM_001243835
Protein Refseq: NP_001230764
MIM: 600558
Uniprot ID: Q14765
Chromosome Location: 2q32.2-q32.3
Pathway: Downstream signaling in naive CD8+ T cells, organism-specific biosystem; IL12 signaling mediated by STAT4, organism-specific biosystem; IL12-mediated signaling events, organism-specific biosystem; IL23-mediated signaling events, organism-specific biosystem; IL27-mediated signaling events, organism-specific biosystem;
Function: calcium ion binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; signal transducer activity;

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