Recombinant Human TNIK

• Cat.No.: TNIK-31580TH
• Product Overview: Recombinant fragment of Human TNIK (amino acids 1-367) with N-terminal proprietary tag, 67kDa inclusive of tag.

Specification

• Description: Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al.
• Protein length: 367 amino acids
• Molecular Weight: 67.000kDa inclusive of tags
• Source: Baculovirus infected sf9 cells
• Tissue specificity: Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues.
• Biological activity: TNIK-31580TH specific activity determined to be 68 nmol/min/mg.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: pH: 7.50Constituents:0.79% Tris HCl, 0.88% Sodium chloride, 25% Glycerol, 0.31% Glutathione, 0.003% EDTA, 0.002% PMSF, 0.003% DTT
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.Contains 1 CNH domain.Contains 1 protein kinase domain.

Gene Information

• Gene Name: TNIK TRAF2 and NCK interacting kinase [ Homo sapiens ]
• Official Symbol: TNIK
• Synonyms: TNIK; TRAF2 and NCK interacting kinase; TRAF2 and NCK-interacting protein kinase; KIAA0551
• Gene ID: 23043
• mRNA Refseq: NM_001161560
• Protein Refseq: NP_001155032
• MIM: 610005
• Uniprot ID: Q9UKE5
• Chromosome Location: 3q26.31
• Pathway: Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem; TNF receptor signaling pathway, organism-specific biosystem
• Function: ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; small GTPase regulator activity