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Recombinant Human TOP1, His-tagged

Cat.No.: TOP1-30912TH
Product Overview: DNA Topoisomerase-I Human Recombinant produced in SF9 is a glycosylated, polypeptide chain having a molecular mass of 91,576 Dalton (excluding glycosilation) 102 kDa total mass. The TOP1 is expressed with a -6xHis tag and purified by proprietary chromatographic techniques.
Description: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22.
Source: Sf9 insect cells.
Species: Human
Tag: His
Form: Sterile Filtered clear solution. TOP1 is supplied in 16mM HEPES buffer pH-7.5, 400mM sodium chloride, and 20% glycerol.
Purity: Greater than 95% as determined by SDS-PAGE.
Storage: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.
Gene Name: TOP1 topoisomerase (DNA) I [ Homo sapiens (human) ]
Official Symbol: TOP1
Synonyms: TOP1; TOPI; topoisomerase (DNA) I; DNA topoisomerase 1; type I DNA topoisomerase; NP_003277.1; EC 5.99.1.2
Gene ID: 7150
mRNA Refseq: NM_003286
Protein Refseq: NP_003277
MIM: 126420
UniProt ID: P11387
Chromosome Location: 20q12-q13.1
Pathway: Caspase cascade in apoptosis; Integrated Pancreatic Cancer Pathway
Function: ATP binding; DNA topoisomerase type I activity; DNA topoisomerase type II (ATP-hydrolyzing) activity

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