|Product Overview :
||Recombinant full length Human GilZ / TilZ isoform 2 with N-terminal proprietary tag.Mol Wt 48.07 kDa inclusive of tag.
||The protein encoded by this gene shares significant sequence identity with the murine TSC-22 and Drosophila shs, both of which are leucine zipper proteins, that function as transcriptional regulators. The expression of this gene is stimulated by glucocorticoids and interleukin 10, and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid and chemokine. Transcript variants encoding different isoforms have been identified for this gene.
|Protein length :
||200 amino acids
|Molecular Weight :
||48.070kDa inclusive of tags
|Tissue specificity :
||Expressed in brain, lung, spleen and skeletal muscle. Lower levels detected in heart and kidney. Not detected in the pancreas. In non-lymphoid tissues, in the absence of inflammation, the major source of constitutive expression is the macrophage lineage.
|Storage buffer :
||pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
||Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
|Sequences of amino acids :
MAQSKLDCRS PVGLDCCNCC LDLAHRSGLQ RGSSGENNNP GSPTVSNFRQ LQEKLVFENL NTDKLNSIMR QDSLEPVLRD PCYLINEGIC NRNIDQTMLS ILLFFHSASG ASVVAIDNKI EQAMDLVKNH LMYAVREEVE ILKEQIRELV EKNSQLEREN TLLKTLASPE QLEKFQSCLS PEEPAPESPQ VPEAPGGSAV
|Sequence Similarities :
||Belongs to the TSC-22/Dip/Bun family.