Recombinant Human SUV39H1, GST-tagged

• Cat.No.: SUV39H1-471H
• Product Overview: Recombinant Human SUV39H1 (amino acids 82-412) was expressed in anE.coliexpression system with N-terminal GST tag. MW=64 kDa.

Specification

• Cat. No.: SUV39H1-471H
• Description: Histone-lysine N-methyltransferase SUV39H1 is an enzyme that in humans is encoded by the SUV39H1 gene.This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating Lys-9 of histone H3. Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression.
• Source: E.Coli.
• Formulated In: 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 30% glycerol, and 3 mM DTT.
• Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
• Purity: > 50%.
• Stability: >6 months at -80°C.

Gene Information

• Gene Name: SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) [ Homo sapiens ]
• Synonyms: suppressor of variegation 3-9 homolog 1 (Drosophila); MG44; KMT1A; SUV39H; SUV39H1; suppressor of variegation 3-9 homolog 1; H3-K9-HMTase 1; Su(var)3-9 homolog 1; histone H3-K9 methyltransferase 1; histone-lysine N-methyltransferase, H3 lysine-9 specific 1; EC 2.1.1.43; OTTHUMP00000024298Histone; H3-K9 methyltransferase 1; Lysine N-methyltransferase 1A; Position-effect variegation 3-9 homolog; Suppressor of variegation 3-9 homolog 1; suppressor of variegation 3-9 (Drosophila) homolog 1
• Gene ID: 6839
• mRNA Refseq: NM_003173
• Protein Refseq: NP_003164
• MIM: 300254
• UniProt ID: O43463
• Chromosome Location: Xp11.23
• Pathway: Lysine degradation
• Function: S-adenosylmethionine-dependent methyltransferase activity; chromatin binding; histone methyltransferase activity (H3-K9 specific); protein N-terminus binding; transferase activity; zinc ion binding