Recombinant Human UNC13D, His-tagged

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Recombinant Human UNC13D, His-tagged

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Cat.No. : UNC13D-28544TH
Product Overview : Recombinant fragment, corresponding to amino acids 861-1090 of Human Munc 13-4 with a N terminal His tag; 34 kDa.
Description : This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder.
Conjugation : HIS
Source : E. coli
Tissue specificity : Expressed at high levels in spleen, thymus and leukocytes. Also expressed in lung and placenta, and at very low levels in brain, heart, skeletal muscle and kidney. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells.
Form : Lyophilised:Reconstitution with 146 μl aqua dest.
Storage buffer : Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
Storage : Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : GCGLPPKALH TATFQALQRD LELQAASSRE LIRKYFCSRI QQQAETTSEE LGAVTVKASY RASEQKLRVE LLSASSLLPL DSNGSSDPFV QLTLEPRHEF PELAARETQK HKKDLHPLFD ETFEFLVPAE PCRKAGACLL LTVLDYDTLG ADDLEGEAFL PLREVPGLSG SEEPGEVPQT RLPLTYPAPN GDPILQLLEG RKGDREAQVF VRLRRHRAKQ ASQHALRPAP
Sequence Similarities : Belongs to the unc-13 family.Contains 2 C2 domains.Contains 1 MHD1 (MUNC13 homology domain 1) domain.Contains 1 MHD2 (MUNC13 homology domain 2) domain.
Gene Name : UNC13D unc-13 homolog D (C. elegans) [ Homo sapiens ]
Official Symbol : UNC13D
Synonyms : UNC13D; unc-13 homolog D (C. elegans); protein unc-13 homolog D; Munc13 4;
Gene ID : 201294
mRNA Refseq : NM_199242
Protein Refseq : NP_954712
MIM : 608897
Uniprot ID : Q70J99
Chromosome Location : 17q25.3
Function : protein binding;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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