Recombinant Human XRCC6, His-tagged

• Cat.No.: XRCC6-31455TH
• Product Overview: Human recombinant Ku70 + Ku80 fragment produced in SF9 insect cells is a glycosylated, polypeptide chain with a 6xHis tag, MW of 44 kDa.

Specification

• Description: The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.
• Conjugation: HIS
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 160mM Sodium chloride, 16mM HEPES, pH 8
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Gene Information

• Gene Name: XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 [ Homo sapiens ]
• Official Symbol: XRCC6
• Synonyms: XRCC6; X-ray repair complementing defective repair in Chinese hamster cells 6; G22P1, thyroid autoantigen 70kD (Ku antigen) , thyroid autoantigen 70kDa (Ku antigen); X-ray repair cross-complementing protein 6; D22S671; D22S731; Ku autoantigen; 70kDa; KU
• Gene ID: 2547
• mRNA Refseq: NM_001469
• Protein Refseq: NP_001460
• MIM: 152690
• Uniprot ID: P12956
• Chromosome Location: 22q13.2
• Pathway: 2-LTR circle formation, organism-specific biosystem; BARD1 signaling events, organism-specific biosystem; Coregulation of Androgen receptor activity, organism-specific biosystem; DNA Repair, organism-specific biosystem; DNA-PK complex, organism-specific biosystem
• Function: 5-deoxyribose-5-phosphate lyase activity; ATP binding; ATP-dependent DNA helicase activity; DNA binding; double-stranded DNA binding