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Recombinant Human Fructose-1,6-bisphosphatase 1, His-tagged

Cat. No. : FBP1-1815H
Product Overview : Recombinant human FBP1 protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW = 39.0 kDa (358aa).
Description : Fructose-1,6-bisphosphatase 1(FBP1) is a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis.
Source : E.coli.
Amino Acid Sequence : MGSSHHHHHH SSGLVPRGSH MADQAPFDTD VNTLTRFVME EGRKARGTGE LTQLLNSLCT AVKAISSAVR KAGIAHLYGI AGSTNVTGDQ VKKLDVLSND LVMNMLKSSF ATCVLVSEED KHAIIVEPEK RGKYVVCFDP LDGSSNIDCL VSVGTIFGIY RKKSTDEPSE KDALQPGRNL VAAGYALYGS ATMLVLAMDC GVNCFMLDPA IGEFILVDKD VKIKKKGKIY SLNEGYARDF DPAVTEYIQR KKFPPDNSAP YGARYVGSMV ADVHRTLVYG GIFLYPANKK SPNGKLRLLY ECNPMAYVME KAGGMATTGK EAVLDVIPTD IHQRAPVILG SPDDVLEFLK VYEKHSAQ
Form : Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 1mM DTT 10% glycerol.
Purity : > 90% by SDS – PAGE.
Concentration : 1 mg/ml (determined by Bradford assay).
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : FBP1 fructose-1,6-bisphosphatase 1 [ Homo sapiens ]
Synonyms : FBP1; fructose-1,6-bisphosphatase 1; FBP; FBPase 1; fructose-bisphosphatase 1; growth-inhibiting protein 17; D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; EC 3.1.3.11; OTTHUMP00000021694
Gene ID : 2203
mRNA Refseq : NM_000507
Protein Refseq : NP_000498
MIM : 611570
UniProt ID : P09467
Chromosome Location : 9q22.3
Pathway : Fructose and mannose metabolism; Glycolysis / Gluconeogenesis; Insulin signaling pathway; Metabolic pathways; Pentose phosphate pathway
Function : fructose 1,6-bisphosphate 1-phosphatase activity; fructose-2,6-bisphosphate 2-phosphatase activity; hydrolase activity; identical protein binding; magnesium ion binding; monosaccharide binding; phosphoric ester hydrolase activity

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