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Recombinant Human Guanidinoacetate N-methyltransferase, His-tagged

Cat. No.: GAMT-483H
Product Overview: Recombinant human GAMT, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW= 28.4 kDa (256aa).
Description: Guanidinoacetate N-methyltransferase isoform a, also known as GAMT is a methyltansferase that converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl domor. This enzyme participates in the two-step synthesis of the compound creatine from the protein building blocks glycine, arginine, and methionine. It is involved in providing energy for muscle contraction, and is also important in nervous system functioning. Also GAMT is active in the liver, pancreas, and kidneys.
Source: E.coli.
Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MSAPSATPIF APGENCSPAW GAAPAAYDAA DTHLRILGKP VMERWETPYM HALAAAASSK GGRVLEVGFG MAIAASKVQE APIDEHWIIE CNDGVFQRLR DWAPRQTHKV IPLKGLWEDV APTLPDGHFD GILYDTYPLS EETWHTHQFN FIKNHAFRLL KPGGVLTYCN LTSWGELMKS KYSDITIMFE ETQVPALLEA GFRRENIRTE VMALVPPADC RYYAFPQMIT PLVTKG
Form: Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 1mM DTT, 10% glycerol.
Purity: > 95% by SDS – PAGE.
Concentration: 1 mg/ml (determined by Bradford assay).
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: GAMT guanidinoacetate N-methyltransferase [ Homo sapiens ]
Synonyms: GAMT; guanidinoacetate N-methyltransferase; PIG2; TP53I2; EC 2.1.1.2
Gene ID: 2593
mRNA Refseq: NM_000156
Protein Refseq: NP_000147
MIM: 601240
UniProt ID: Q14353
Chromosome Location: 19p13.3
Pathway: Arginine and proline metabolism; Glycine, serine and threonine metabolism; Metabolic pathways
Function: guanidinoacetate N-methyltransferase activity; methyltransferase activity; transferase activity

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