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Recombinant Human Ketohexokinase

Cat. No.: KHK-491H
Product Overview: Recombinant human Ketohexokinase was expressed inE.coliand purified by using conventional chromatography.
Description: Ketohexokinase is an enzyme that catalyzes the phosphorylation of fructose to produce fructose-1-phosphate, leading to consumption of ATP, formation of AMP. This protein initiates first step in the metabolism of dietary fructose and is an important regulator of hepatic glucose metabolism. It is highly found in liver, renal cortex, and small intestine. Its deficiency causes the benign hereditary metabolic disorder essential fructosuria, leading to fructose being excreted in the urine.
Sequences of amino acids: MEEKQILCVG LVVLDVISLV DKYPKEDSEI RCLSQRWQRG GNASNSCTIL SLLGAPCAFM GSMAPGHVAD FVLDDLRRYS VDLRYTVFQT TGSVPIATVI INEASGSRTI LYYDRSLPDV SATDFEKVDL TQFKWIHIEG RNASEQVKML QRIDAHNTRQ PPEQKIRVSV EVEKPREELF QLFGYGDVVF VSKDVAKHLG FQSAEEALRG LYGRVRKGAV LVCAWAEEGA DALGPDGKLL HSDAFPPPRV VDTLGAGDTF NASVIFSLSQ GRSVQEALRF GCQVAGKKCG LQGFDGIV
Form: Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol
Molecular Weight: 32.7 kDa (298aa)
Purity: > 90% by SDS - PAGE
Concentration: 1 mg/ml (determined by Bradford assay)
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Pathways: Fructose and mannose metabolism; Metabolic pathways; Metabolism of carbohydrates
Gene Name: KHK ketohexokinase (fructokinase) [ Homo sapiens ]
Synonyms: KHK; ketohexokinase (fructokinase); ketohexokinase; EC 2.7.1.3; ketohexokinase; Hepatic fructokinase;
Gene ID: 3795
mRNA Refseq: NM_000221
Protein Refseq: NP_000212
MIM: 229800
UniProt ID: P50053
Chromosome Location: 2p23.3
Function: ATP binding; ketohexokinase activity; kinase activity; nucleotide binding; protein binding; transferase activity

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