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Recombinant Human Capping Protein (actin filament), Gelsolin-like

Cat. No.: CAPG-1826H
Product Overview: Recombinant human CAPG was expressed in E.coli and purified by using conventional chromatography techniques.
Description: Macrophage-capping protein, also known as CAPG, belongs to the gelsolin/villin family of actin-regulatory proteins. CAPG is a calcium-sensitive DNA-binding protein that plays a role in macrophage function. It is expressed in macrophages and macrophage-like cells and can localize both to the nucleus and the cytoplasm. This protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments.
Sequences of amino acids: MYTAIPQSGS PFPGSVQDPG LHVWRVEKLK PVPVAQENQG VFFSGDSYLV LHNGPEEVSH LHLWIGQQSS RDEQGACAVL AVHLNTLLGE RPVQHREVQG NESDLFMSYF PRGLKYQEGG VESAFHKTST GAPAAIKKLY QVKGKKNIRA TERALNWDSF NTGDCFILDL GQNIFAWCGG KSNILERNKA RDLALAIRDS ERQGKAQVEI VTDGEEPAEM IQVLGPKPAL KEGNPEEDLT ADKANAQAAA LYKVSDATGQ MNLTKVADSS PFALELLISD DCFVLDNGLC GKIYIWKGRK ANEKERQAAL QVAEGFISRM QYAPNTQVEI LPQGRESPIF KQFFKDWK
Form: Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 1mM DTT, 10% glycerol
Molecular Weight: 38.5 kDa (348aa)
Purity: > 95% by SDS - PAGE
Concentration: 1 mg/ml (determined by Bradford assay)
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: CAPG capping protein (actin filament), gelsolin-like [ Homo sapiens ]
Synonyms: CAPG; AFCP; MCP; capping protein (actin filament), gelsolin-like; gelsolin-like capping protein; OTTHUMP00000203057; OTTHUMP00000203058; macrophage capping protein; actin-regulatory protein CAP-G; Actin regulatory protein CAP-G.
Gene ID: 822
mRNA Refseq: NM_001747
Protein Refseq: NP_001738
MIM: 153615
UniProt ID: P40121
Chromosome Location: 2p11.2
Function: actin binding

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