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Recombinant Human Ornithine Aminotransferase

Cat. No. : OAT-493H
Product Overview : Recombinant human OAT protein was expressed inE.coliand purified by using conventional chromatography techniques. MW = 45.2 kDa (408aa).
Description : OAT, also known as mitochondrial enzyme ornithine aminotransferase, is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. ( L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid.) Mutations that result in a deficiency of this enzyme cause the autosomal recessive eye disease Gyrate Atrophy.
Source : E.coli.
Form : Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol.
Purity : > 90% by SDS – PAGE.
Concentration : 1 mg/ml (determined by Bradford assay).
Sequences Of Amino Acids : MTVQGPPTSD DIFEREYKYG AHNYHPLPVA LERGKGIYLW DVEGRKYFDF LSSYSAVNQG HCHPKIVNAL KSQVDKLTLT SRAFYNNVLGEYEEYITKLF NYHKVLPMNT GVEAGETACK LARKWGYTVK GIQKYKAKIV FAAGNFWGRT LSAISSSTDP TSYDGFGPFM PGFDIIPYNDLPALERALQD PNVAAFMVEP IQGEAGVVVP DPGYLMGVRE LCTRHQVLFI ADEIQTGLAR TGRWLAVDYE NVRPDIVLLG KALSGGLYPVSAVLCDDDIM LTIKPGEHGS TYGGNPLGCR VAIAALEVLE EENLAENADK LGIILRNELM KLPSDVVTAV RGKGLLNAIV IKETKDWDAWKVCLRLRDNG LLAKPTHGDI IRFAPPLVIK EDELRESIEI INKTILSF.
Storage : can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : OAT ornithine aminotransferase [ Homo sapiens ]
Synonyms : ornithine aminotransferase; HOGA; OATASE; DKFZp781A11155; OAT; ornithine aminotransferase, mitochondrial; gyrate atrophy; ornithine-delta-aminotransferase; ornithine-oxo-acid aminotransferase; ornithine--oxo-acid aminotransferase; ornithine aminotransferase (gyrate atrophy); EC 2.6.1.13
Gene ID : 4942
mRNA Refseq : NM_000274
Protein Refseq : NP_000265
MIM : 258870
UniProt ID : P04181
Chromosome Location : 10q26
Pathway : Arginine and proline metabolism; Metabolic pathways; Metabolism of amino acids and derivatives
Function : ornithine-oxo-acid transaminase activity; protein binding; pyridoxal phosphate binding; transferase activity

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