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Active Recombinant Human ACACB protein, His-tagged

Cat.No. : ACACB-1849H
Product Overview : Recombinant full length Human ACACB fused with His tag at N-terminal was expressed in Insect cells.
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  • Gene Information
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Description : Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms.
Source : Insect cells
Species : Human
Tag : His
Form : 40 mM Tris pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, 20% glycerol, and 3 mM DTT.
Bio-activity : ≥41 pmoles/min/µg
Molecular Mass : 277 kDa
Purity : >56%
Applications : Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Storage : >6 months at –80 centigrade. Avoid freeze/thaw cycles.
Concentration : 0.07 mg/ml
Gene Name : ACACB acetyl-CoA carboxylase beta [ Homo sapiens ]
Official Symbol : ACACB
Synonyms : ACACB; acetyl-CoA carboxylase beta; acetyl Coenzyme A carboxylase beta; acetyl-CoA carboxylase 2; ACC2; ACCB; acetyl CoA carboxylase 2; HACC275; ACC-beta; acetyl-Coenzyme A carboxylase beta;
Gene ID : 32
mRNA Refseq : NM_001093
Protein Refseq : NP_001084
MIM : 601557
UniProt ID : O00763
Chromosome Location : 12q24.1
Pathway : AMPK signaling, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; ChREBP activates metabolic gene expression, organism-specific biosystem; Fatty Acid Biosynthesis, organism-specific biosystem; Fatty acid biosynthesis, organism-specific biosystem; Fatty acid biosynthesis, conserved biosystem;
Function : ATP binding; acetyl-CoA carboxylase activity; biotin carboxylase activity; ligase activity; metal ion binding; nucleotide binding; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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What are the downstream targets of acetyl-CoA carboxylase beta protein in lipid synthesis? 07/31/2022

The downstream targets of acetyl-CoA carboxylase beta protein include fatty acid synthase and other enzymes involved in lipid synthesis.

What is the role of acetyl-CoA carboxylase beta protein in lipid metabolism? 02/15/2021

Acetyl-CoA carboxylase beta protein is responsible for the carboxylation of acetyl-CoA, which is a key step in fatty acid synthesis.

How does acetyl-CoA carboxylase beta protein contribute to insulin resistance and metabolic diseases? 01/21/2021

Acetyl-CoA carboxylase beta protein has been implicated in the development of insulin resistance and metabolic diseases due to its role in lipid metabolism.

How is acetyl-CoA carboxylase beta protein regulated in the cell? 02/04/2020

Acetyl-CoA carboxylase beta protein is regulated by various post-translational modifications and allosteric regulators.

What is the structure of acetyl-CoA carboxylase beta protein? 06/21/2019

Acetyl-CoA carboxylase beta protein is a multi-domain protein composed of several structural domains.

How does acetyl-CoA carboxylase beta protein interact with other proteins in lipid metabolism pathways? 06/26/2018

Acetyl-CoA carboxylase beta protein interacts with several other proteins involved in lipid metabolism, including fatty acid synthase and AMP-activated protein kinase.

What is the function of acetyl-CoA carboxylase beta protein in the body? 04/12/2018

Acetyl-CoA carboxylase beta protein plays a crucial role in fatty acid metabolism and lipid synthesis.

What is the expression pattern of acetyl-CoA carboxylase beta protein in different tissues? 06/26/2017

Acetyl-CoA carboxylase beta protein is expressed in various tissues, with the highest expression observed in the liver and adipose tissue.

What are the genetic variants associated with acetyl-CoA carboxylase beta protein and metabolic disorders? 10/17/2016

Several genetic variants in the acetyl-CoA carboxylase beta gene have been associated with metabolic disorders such as obesity and type 2 diabetes.

What are the potential therapeutic targets for regulating acetyl-CoA carboxylase beta protein activity? 06/27/2016

Potential therapeutic targets for regulating acetyl-CoA carboxylase beta protein activity include small molecule inhibitors and modulators of its regulatory pathways.

Customer Reviews (2)

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Reviews
09/05/2022

    Demonstrates high selectivity and sensitivity in detecting protein-protein interactions in pull-down assays.

    02/18/2018

      Provides accurate and reliable quantification of protein biomarkers in clinical samples.

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