"ACACB" Related Products


Recombinant Human ACACB protein, His-tagged

Cat.No. : ACACB-1849H
Product Overview : Recombinant full length Human ACACB fused with His tag at N-terminal was expressed in Insect cells.
Description : Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms.
Source : Insect cells
Species : Human
Tag : His
Form : 40 mM Tris pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, 20% glycerol, and 3 mM DTT.
Bio-activity : ≥41 pmoles/min/µg
Molecular Mass : 277 kDa
Purity : >56%
Applications : Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Storage : >6 months at –80 centigrade. Avoid freeze/thaw cycles.
Concentration : 0.07 mg/ml
Gene Name : ACACB acetyl-CoA carboxylase beta [ Homo sapiens ]
Official Symbol : ACACB
Synonyms : ACACB; acetyl-CoA carboxylase beta; acetyl Coenzyme A carboxylase beta; acetyl-CoA carboxylase 2; ACC2; ACCB; acetyl CoA carboxylase 2; HACC275; ACC-beta; acetyl-Coenzyme A carboxylase beta;
Gene ID : 32
mRNA Refseq : NM_001093
Protein Refseq : NP_001084
MIM : 601557
UniProt ID : O00763
Chromosome Location : 12q24.1
Pathway : AMPK signaling, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; ChREBP activates metabolic gene expression, organism-specific biosystem; Fatty Acid Biosynthesis, organism-specific biosystem; Fatty acid biosynthesis, organism-specific biosystem; Fatty acid biosynthesis, conserved biosystem;
Function : ATP binding; acetyl-CoA carboxylase activity; biotin carboxylase activity; ligase activity; metal ion binding; nucleotide binding; protein binding;

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