Active Recombinant Human Activin A Receptor, Type IB

• Cat.No.: ACVR1B-1916H
• Product Overview: Recombinant HumanActivin A Receptor, Type IB was expressed inhuman 293 cells.

Specification

• Cat. No.: ACVR1B-1916H
• Description: Xeno-free Activin AHuXp is a member of the TGF beta superfamily, expressed from human 293 cells as disulfide linked homodimer with an apparent molecular mass of 25 kDa. This cytokine is produced in a serum-free, chemically defined media. The purity is greater than 95%.
• Source: Human 293 cells.
• Activity: 0.5 to 5 ng/mL ED50.
• Purity: >95%.
• Endotoxin: Endotoxin-free.
• Molecular Mass: 25 kDa, homodimer, nonglycosylated.
• Purity Confirmation: The protein was resolved by SDS polyacrylamide gel electrophoresis and the gel was stained with Coomassie blue.
• Activity Assay: The specific activity was determined by the dose-dependent inhibition of proliferation of the MPC-11 cell line (mouse plasmocytoma cell line).

Gene Information

• Gene Name: ACVR1B activin A receptor, type IB [ Homo sapiens ]
• Synonyms: ACVR1B; activin A receptor, type IB; ALK4; SKR2; ACTRIB; ACVRLK4; ACVR1B; ActRIB; Activin receptor-like kinase 42; Serine/threonine-protein kinase receptor R2; ActRIB; serine(threonine) protein kinase receptor R2
• Gene ID: 91
• mRNA Refseq: NM_004302
• Protein Refseq: NP_004293
• MIM: 601300
• UniProt ID: P36896
• Chromosome Location: 12q13
• Pathway: Adherens junction; Chronic myeloid leukemia; Colorectal cancer; Cytokine-cytokine receptor interaction; Endocytosis; MAPK signaling pathway; Pancreatic cancer; Pathways in cancer; TGF-beta signaling pathway
• Function: ATP binding; SMAD binding; activin binding; activin receptor activity; activin receptor activity, type I; growth factor binding; metal ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; receptor activity; transferase activity; transmembrane receptor protein serine/threonine kinase activity; ubiquitin protein ligase binding