Recombinant Human CTLA4, Fc Chimera
Cat.No. : | CTLA4-1913H |
Product Overview : | Recombinant Human CTLA-4 produced inE.Coliis a homodimeric, non-glycosylated polypeptide chain containing a total molecular mass of 80 kDa. Each subunit (40kDa) is fused to a polypeptide linker to the Fc portion of Human IgG1. rHuCTLA-4 is purified by proprietary chromatographic techniques. |
- Specification
- Gene Information
- Related Products
Cat. No. : | CTLA4-1913H |
Description : | CTLA-4 is expressed in low copy number by T-cells only after activation, but it binds CD28-ligand with approximately 20-fold higher affinity than CD28. A soluble form of the extracellular domain of CTLA-4 has been shown to bind CD28-ligand with high avidity and to suppress T-cell-dependent antibody responses in vivo. Large doses of this soluble protein also suppress responses to a second immunization. |
Source : | E.Coli. |
Amino Acid Sequence : | The sequence of the first five N-terminal amino acids was determined and was found to be Lys-Ala-Met-His-Val. |
Form : | Purified. |
Purity : | Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Anion-exchange FPLC. |
Dimers & Aggregates : | <1% as determined by silver stained SDS-PAGE gel analysis. |
Endotoxin : | < 0.1 ng/µg (IEU/µg) of rHuCTLA-4. |
Protein Content : | Protein quantitation was carried out by two independent methods: 1) UV spectroscopy at 280 nm. 2) Analysis by RP-HPLC, using a standard solution of CTLA-4 as a Reference Standard. |
Application : | 1) Molecular standard (Western, ELISA) in studying secreted BMP-4. 2) Preparing antibodies for BMP-4 monomer. 3) Molecule standard in detecting secreted BMP-4 in reduced SDS-PAGE. |
Biological Activity : | rHuCTLA-4 is fully biologically active when compared to standards. |
Storage : | -20°C, avoid freezing and thawing cycles after reconstitution. |
Gene Name : | CTLA4 cytotoxic T-lymphocyte-associated protein 4 [ Homo sapiens ] |
Synonyms : | CTLA4; cytotoxic T-lymphocyte- associated protein 4; CD; CD28; CD152; CD152; CELIAC3; CTLA-4; celiac disease 3; Cytotoxic T-lymphocyte protein 4; cytotoxic T-lymphocyte antigen 4; cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymphocyte-associated serine esterase-4; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4; ICOS; GSE; IDDM12; IDDM12; CTLA-4; OTTHUMP00000163781 |
Gene ID : | 1493 |
mRNA Refseq : | NM_001037631 |
Protein Refseq : | NP_001032720 |
MIM : | 123890 |
UniProt ID : | P16410 |
Chromosome Location : | 2q33 |
Pathway : | Autoimmune thyroid disease ; Cell adhesion molecules (CAMs); T cell receptor signaling pathway |
Function : | Protein binding |
Products Types
◆ Recombinant Protein | ||
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Ctla4-158M | Recombinant Mouse Ctla4 Protein, His (Fc)-Avi-tagged | +Inquiry |
Ctla4-651H | Recombinant Human Ctla4 Protein, IgG2a Fc-tagged | +Inquiry |
CTLA4-109C | Active Recombinant Cynomolgus/Rhesus CTLA4 protein(Met1-Asp161), His-tagged | +Inquiry |
◆ Lysates | ||
CTLA4-2526HCL | Recombinant Human CTLA4 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1712 | CTLA4:B7-1[Biotinylated] Inhibitor Screening Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, several clinical trials are investigating the combination of CTLA-4 inhibitors with PD-1 inhibitors and other immunotherapies to improve the overall effectiveness of cancer treatment.
CTLA-4 is expressed on various immune cells, including T cells, regulatory T cells (Tregs), and some B cells, contributing to its diverse immunoregulatory functions.
Modulating CTLA-4 may have applications in organ transplantation by suppressing the immune response against transplanted tissues and reducing the risk of rejection.
CTLA-4 is involved in the suppression of autoreactive T cells, contributing to the prevention of autoimmune responses by maintaining immune tolerance.
While both CTLA-4 and PD-1/PD-L1 inhibitors enhance anti-tumor immune responses, they target different checkpoints in the immune system. CTLA-4 primarily regulates T-cell activation in the early stages, whereas PD-1/PD-L1 acts later in the immune response.
Customer Reviews (3)
Write a reviewIt has become an indispensable tool in my experiments, consistently meeting my needs and providing valuable insights.
The CTLA4 protein is a top-quality product that is sure to fulfill my experimental requirements.
the ease of use and compatibility of the CTLA4 protein with various techniques further enhances its appeal.
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