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Recombinant Mouse Lymphocyte-Activation Gene 3, Fc Chimera

Cat. No.: Lag3-2089M
Product Overview: Recombinant MouseLag3 Produced inCHO cells.The sequence coding for the 4 extracellular Ig-like domains of mouse LAG-3 (D1-D4) is fused to the Fc portion of mouse IgG2a (hinge-CH2-CH3). MW=180kDa (SPS-PAGE, nonreducing), ~80kDa (SPS-PAGE, reducing).
Description: The lymphocyte activation gene-3 (LAG-3, CD223), a member of the immunoglobulin superfamily (IgSF) related to CD4, binds to the major histocompatibility complex (MHC) class II molecules but with higher affinity than CD4. Several alternative mRNA splice-variants of human LAG-3 have been described, two of them encoding potential secreted forms: LAG-3V1 (i.e. the D1-D2 domains of the protein, 36 kDa) and LAG-3V3 (D1-D3, 52 kDa).
Source: CHO cells.
Concentration: 0.5mg/ml.
Purity: ≥95% (SDS-PAGE).
Formulation: Liquid. In PBS.
Endotoxin Content: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
Reconstitution: Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
Specificity: Binds to human and mouse MHC class II.
Biological Activity: Induces maturation of mouse dendritic cells in vitro. Induces CD4 and CD8 antigen-specific T cells responses when coinjected s.c. in mice, together with the antigen.
Application: Flow Cytometry.
Long Trem Storage: +4°C.
Stability: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at+4°C.
Gene Name: Lag3 lymphocyte-activation gene 3 [ Mus musculus ]
Synonyms: Lag3; lymphocyte-activation gene 3; Ly66; CD223; LAG-3
Gene ID: 16768
mRNA Refseq: NM_008479
Protein Refseq: NP_032505
UniProt ID: Q61790
Chromosome Location: 6 F2
Function: MHC class II protein binding; transmembrane receptor activity

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