Recombinant Human Caspase 10, Apoptosis-related Cysteine Peptidase

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Recombinant Human Caspase 10, Apoptosis-related Cysteine Peptidase

CASP10 Related Products

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Cat. No. : CASP10-598H
Description : Caspase-10 (also known as Mch4 and Flice2) is a member of the interleukin-1b converting enzyme (ICE) family of cysteine proteases. Similar as other caspases, caspase-10 exists in cells as an inactive proenzyme. During apoptosis, procaspase-10 is processed at aspartate residues by self-proteolysis and/or cleavage by upstream caspases. The processed form of caspase-10 consists of large (18kDa) and small (11kDa) subunits which associate to form the active enzyme.
Sourse/Host : E. coli.
Formulation : Lyophilized.
Reconstitution : Reconstitute with PBS to 1U/µl.
Specific Activity : ~15"000U/mg protein. One unit is defined as the amount of enzyme that cleaves 1nmol of the caspase substrate IETD-pNA per hour at 37°C in a reaction solution containing 50mM HEPES, pH 7.2, 50mM NaCl, 0.1% CHAPS, 10mM EDTA, 5% glycerol and 10mM DTT.
Purity : ≥90% (SDS-PAGE).
Storage : For long term storage, -80°C.
Pathways : Apoptosis; RIG-I-like receptor signaling pathway
Gene Name : CASP10 caspase 10, apoptosis-related cysteine peptidase [ Homo sapiens ]
Synonyms : caspase 10, apoptosis-related cysteine peptidase; MCH4; ALPS2; FLICE2; CASP10; caspase-10; CASP-10; FADD-like ICE2; apoptotic protease MCH-4; ICE-like apoptotic protease 4; interleukin-1B-converting enzyme 2; caspase 10, apoptosis-related cysteine protease; FAS-associated death domain protein interleukin-1B-converting enzyme 2;Apoptotic protease Mch-4; Fas-associated death domain protein; EC 3.4.22.63
Gene ID : 843
mRNA Refseq : NM_001230
Protein Refseq : NP_001221
MIM : 601762
UniProt ID : Q92851
Chromosome Location : 2q33-q34
Function : cysteine-type endopeptidase activity; identical protein binding; peptidase activity; protein binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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