Recombinant Mouse CREB Binding Protein, His-tagged
Cat.No. : | Crebbp-2103M |
Product Overview : | Recombinant Mouse Crebbp produced inSF21 cells.Fused to a His-tag. |
- Specification
- Gene Information
- Related Products
Cat. No. : | Crebbp-2103M |
Description : | First isolated as a nuclear protein that binds to cAMP-response element-binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. |
Source : | SF21 cells. |
Concentration : | 0.5mg/ml. |
Purity : | ≥95% (SDS-PAGE). |
Formulation : | Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50-100mM imidazole and 10% glycerol. |
Specific Activity : | ~50-100ng are required for standard HAT assay. |
Term Storage : | -80°C. |
Handling : | After opening, prepare aliquots and store in liquid nitrogen. Avoid freeze/thaw cycles. |
Gene Name : | Crebbp CREB binding protein [ Mus musculus ] |
Synonyms : | Crebbp; CREB binding protein; CBP; RSTS; KAT3A; AW558298; CBP/p300; p300/CBP; EC 2.3.1.48; CREB - binding protein |
Gene ID : | 12914 |
mRNA Refseq : | NM_001025432 |
Protein Refseq : | NP_001020603 |
UniProt ID : | P45481.2 |
Chromosome Location : | 16 A1 |
Pathway : | Adherens junction; Cell cycle; Huntington"s disease; Jak-STAT signaling pathway; Long-term potentiation; Notch signaling pathway; Pathways in cancer; Prostate cancer; Renal cell carcinoma; Melanogenesis; TGF-beta signaling pathway; Wnt signaling pathway; Gene Expression; Metabolism of lipids and lipoproteins |
Function : | DNA binding; SMAD binding; acetyltransferase activity; histone acetyltransferase activity; metal ion binding; peroxisome proliferator activated receptor binding; signal transducer activity; transcription coactivator activity; transcription coactivator activity; transcription factor activity; transferase activity; zinc ion binding |
Products Types
◆ Recombinant Protein | ||
CREBBP-001H | Recombinant Human CREBBP Protein, GST-tagged | +Inquiry |
CREBBP-22HCL | Recombinant Human CREBBP 293 Cell Lysate | +Inquiry |
CREBBP-01D | Recombinant Dog Crebbp Protein, His tagged | +Inquiry |
CREBBP-847R | Recombinant Rhesus Macaque CREBBP Protein, His (Fc)-Avi-tagged | +Inquiry |
CREBBP-1852H | Recombinant Human CREBBP Protein, GST-tagged | +Inquiry |
◆ Assay kits | ||
Kit-1710 | CREBBP Inhibitor Screening Assay Kit | +Inquiry |
Kit-1711 | CREBBP TR-FRET Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionDiscovering novel CREBBP inhibitors is crucial due to the limited number of reported inhibitors, and there is a need to enhance the activity and selectivity of existing compounds.
The bromodomain in CREBBP is linked to its involvement in cancer and other disease processes.
CREBBP stands for CREB-binding protein.
CREBBP serves as a coactivator for the cAMP response element-binding protein (CREB) transcription factor. It plays a crucial role in gene activation.
Research on small molecule inhibitors of CREBBP is in its early stages, with only a few inhibitors reported. Improvements in activity and selectivity are needed for these compounds.
CREBBP belongs to the third category of structural domain proteins, and it shares homology with its counterpart EP300.
CREBBP contains a bromodomain, which is associated with the development of cancer and other diseases.
Customer Reviews (3)
Write a reviewThe product's adaptability to custom protocols empowered us to explore innovative experimental setups.
The reduced environmental impact of the product was a responsible choice that resonated with our values.
Customized solutions offered by the manufacturer increased the product's utility in our research.
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