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Recombinant Mouse CREB Binding Protein, His-tagged

Cat. No.: Crebbp-2103M
Product Overview: Recombinant Mouse Crebbp produced inSF21 cells.Fused to a His-tag.
Description: First isolated as a nuclear protein that binds to cAMP-response element-binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex.
Source: SF21 cells.
Concentration: 0.5mg/ml.
Purity: ≥95% (SDS-PAGE).
Formulation: Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50-100mM imidazole and 10% glycerol.
Specific Activity: ~50-100ng are required for standard HAT assay.
Term Storage: -80°C.
Handling: After opening, prepare aliquots and store in liquid nitrogen. Avoid freeze/thaw cycles.
Gene Name: Crebbp CREB binding protein [ Mus musculus ]
Synonyms: Crebbp; CREB binding protein; CBP; RSTS; KAT3A; AW558298; CBP/p300; p300/CBP; EC 2.3.1.48; CREB - binding protein
Gene ID: 12914
mRNA Refseq: NM_001025432
Protein Refseq: NP_001020603
UniProt ID: P45481.2
Chromosome Location: 16 A1
Pathway: Adherens junction; Cell cycle; Huntington"s disease; Jak-STAT signaling pathway; Long-term potentiation; Notch signaling pathway; Pathways in cancer; Prostate cancer; Renal cell carcinoma; Melanogenesis; TGF-beta signaling pathway; Wnt signaling pathway; Gene Expression; Metabolism of lipids and lipoproteins
Function: DNA binding; SMAD binding; acetyltransferase activity; histone acetyltransferase activity; metal ion binding; peroxisome proliferator activated receptor binding; signal transducer activity; transcription coactivator activity; transcription coactivator activity; transcription factor activity; transferase activity; zinc ion binding

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