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Recombinant Mouse CREB Binding Protein, His-tagged

Cat.No. : Crebbp-2103M
Product Overview : Recombinant Mouse Crebbp produced inSF21 cells.Fused to a His-tag.
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Cat. No. : Crebbp-2103M
Description : First isolated as a nuclear protein that binds to cAMP-response element-binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex.
Source : SF21 cells.
Concentration : 0.5mg/ml.
Purity : ≥95% (SDS-PAGE).
Formulation : Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50-100mM imidazole and 10% glycerol.
Specific Activity : ~50-100ng are required for standard HAT assay.
Term Storage : -80°C.
Handling : After opening, prepare aliquots and store in liquid nitrogen. Avoid freeze/thaw cycles.
Gene Name : Crebbp CREB binding protein [ Mus musculus ]
Synonyms : Crebbp; CREB binding protein; CBP; RSTS; KAT3A; AW558298; CBP/p300; p300/CBP; EC 2.3.1.48; CREB - binding protein
Gene ID : 12914
mRNA Refseq : NM_001025432
Protein Refseq : NP_001020603
UniProt ID : P45481.2
Chromosome Location : 16 A1
Pathway : Adherens junction; Cell cycle; Huntington"s disease; Jak-STAT signaling pathway; Long-term potentiation; Notch signaling pathway; Pathways in cancer; Prostate cancer; Renal cell carcinoma; Melanogenesis; TGF-beta signaling pathway; Wnt signaling pathway; Gene Expression; Metabolism of lipids and lipoproteins
Function : DNA binding; SMAD binding; acetyltransferase activity; histone acetyltransferase activity; metal ion binding; peroxisome proliferator activated receptor binding; signal transducer activity; transcription coactivator activity; transcription coactivator activity; transcription factor activity; transferase activity; zinc ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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Why is the discovery of new CREBBP inhibitors urgent? 07/20/2022

Discovering novel CREBBP inhibitors is crucial due to the limited number of reported inhibitors, and there is a need to enhance the activity and selectivity of existing compounds.

What is the significance of the bromodomain in CREBBP? 06/27/2022

The bromodomain in CREBBP is linked to its involvement in cancer and other disease processes.

What does CREBBP stand for? 08/25/2020

CREBBP stands for CREB-binding protein.

What is the role of CREBBP in cellular function? 03/19/2019

CREBBP serves as a coactivator for the cAMP response element-binding protein (CREB) transcription factor. It plays a crucial role in gene activation.

What is the current status of CREBBP small molecule inhibitors? 04/03/2016

Research on small molecule inhibitors of CREBBP is in its early stages, with only a few inhibitors reported. Improvements in activity and selectivity are needed for these compounds.

In which category of structural domain proteins does CREBBP belong? 02/14/2016

CREBBP belongs to the third category of structural domain proteins, and it shares homology with its counterpart EP300.

How many structural domains does CREBBP have? 02/01/2016

CREBBP contains a bromodomain, which is associated with the development of cancer and other diseases.

Customer Reviews (3)

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Reviews
04/17/2021

    The product's adaptability to custom protocols empowered us to explore innovative experimental setups.

    01/29/2019

      The reduced environmental impact of the product was a responsible choice that resonated with our values.

      11/15/2016

        Customized solutions offered by the manufacturer increased the product's utility in our research.

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