"Dkk1" Related Products


Recombinant Mouse Dickkopf Homolog 1 (Xenopus laevis), His-tagged

Cat. No.: Dkk1-2114M
Product Overview: Recombinant Mouse Dkk1 fused with N-terminal his-tag was expressed inE. coli.MW =35 kDa.
Description: Dkk-1 (Dickkopf or Dickkopf-1) is a secreted inhibitor of the Wnt/canonical signaling pathway which mediates a variety of cellular processes. Wnt proteins are extracellular signaling molecules that initiate activation of the canonical pathway by binding low-density lipoprotein receptor-related protein 5&6 (LRP5/6) coreceptors, triggering a cascade of events that stabilize beta-catenin. Wnts mediate osteoblast development and cell-to-cell interactions during embryogenesis, and are also responsible for regulating bone mass in adults during normal bone remodeling processes. Wnts are also found to be expressed during the stationary phase of the cell cycle and are thought to control expansion of bone marrow stromal cells preventing overpopulation in marrow.
Source: E. coli.
Purity: > 95% (SDS-PAGE and Western Blot).
Formulation: Liquid. 50 mM Tris pH 8.5, 250 mM NaCl, 2 mM DTT, 1 mM EDTA.
Application: Western blot Control.
Storage: Store at -70°C.
Gene Name: Dkk1 dickkopf homolog 1 (Xenopus laevis) [ Mus musculus ]
Synonyms: Dkk1; dickkopf homolog 1 (Xenopus laevis); mdkk-1; dickkopf-related protein 1; dkk-1; dickkopf-1; OTTMUSP00000022079
Gene ID: 13380
mRNA Refseq: NM_010051
Protein Refseq: NP_034181
UniProt ID: O54908
Chromosome Location: 19 C2
Pathway: Wnt signaling pathway
Function: low-density lipoprotein receptor binding; protein binding

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