Recombinant Human Ectodysplasin A, FLAG-tagged

• Cat.No.: EDA-2117H
• Product Overview: Recombinant Human EDA was produced inE. coli.The extracellular domain of human EDA-A1 (ectodysplasin-A1) (aa 245-391) is fused at the N-terminus to a linker peptide (9 aa) and a FLAG-tag.

Specification

• Species: Human
• Source: E.coli
• Tag: Flag
• Protein Length: 245-391 a.a.
• Description: The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene.
• Purity: ≥95% (SDS-PAGE).
• Formulation: Lyophilized. Contains PBS.
• Concentration: 0.1mg/ml after reconstitution.
• Endotoxin Content: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
• Reconstitution: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
• Specificity: Binds to human EDAR (ectodysplasin-A1 receptor).
• Stability: Stable for at least 6 months after receipt when stored at -20°C.

Gene Information

• Gene Name: EDA ectodysplasin A [ Homo sapiens ]
• Synonyms: EDA; ectodysplasin A; ED1; HED; EDA1; EDA2; XHED; XLHED; ED1-A1; ED1-A2; STHAGX1; ectodysplasin-A; ectodermal dysplasia protein; X-linked anhidroitic ectodermal dysplasia protein; ectodermal dysplasia 1, anhidrotic; EDA protein; Ectodysplasin-A, membrane form; Ectodysplasin-A, secreted form
• Gene ID: 1896
• mRNA Refseq: NM_001005609
• Protein Refseq: NP_001005609
• MIM: 300451
• UniProt ID: Q92838
• Chromosome Location: Xq12-q13.1
• Pathway: Cytokine-cytokine receptor interaction
• Function: protein binding; receptor binding; tumor necrosis factor receptor binding