"EDA" Related Products

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Recombinant Human Ectodysplasin A, FLAG-tagged

Cat. No. : EDA-2117H
Product Overview : Recombinant Human EDA was produced inE. coli.The extracellular domain of human EDA-A1 (ectodysplasin-A1) (aa 245-391) is fused at the N-terminus to a linker peptide (9 aa) and a FLAG-tag.
Description : The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene.
Source : E. coli.
Purity : ≥95% (SDS-PAGE).
Formulation : Lyophilized. Contains PBS.
Concentration : 0.1mg/ml after reconstitution.
Endotoxin Content : <0.1EU/µg purified protein (LAL test; Bio Whittaker).
Reconstitution : Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
Specificity : Binds to human EDAR (ectodysplasin-A1 receptor).
Stability : Stable for at least 6 months after receipt when stored at -20°C.
PDB rendering based on 1rj7. :

Gene Name : EDA ectodysplasin A [ Homo sapiens ]
Synonyms : EDA; ectodysplasin A; ED1; HED; EDA1; EDA2; XHED; XLHED; ED1-A1; ED1-A2; STHAGX1; ectodysplasin-A; ectodermal dysplasia protein; X-linked anhidroitic ectodermal dysplasia protein; ectodermal dysplasia 1, anhidrotic; EDA protein; Ectodysplasin-A, membrane form; Ectodysplasin-A, secreted form
Gene ID : 1896
mRNA Refseq : NM_001005609
Protein Refseq : NP_001005609
MIM : 300451
UniProt ID : Q92838
Chromosome Location : Xq12-q13.1
Pathway : Cytokine-cytokine receptor interaction
Function : protein binding; receptor binding; tumor necrosis factor receptor binding

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