Recombinant Human Profilin Family, Member 4, His-tagged

• Cat.No.: PFN4-2045H
• Product Overview: Recombinant human Profilin-4, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques, 16.4 kDa (149aa).

Specification

• Cat. No.: PFN4-2045H
• Description: HRAS, also known as GTPase HRas, belongs to the Ras family which function in signal transduction pathways. This protein can bind GTP and GDP, and it has intrinsic GTPase activity. HRAS undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. Defects in HRAS are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma.
• Source: E.coli.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol.
• Purity: > 95% by SDS - PAGE.
• Concentration: 0.5 mg/ml (determined by Bradford assay).
• Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MSHLQSLLLD TLLGTKHVDS AALIKIQERS LCVASPGFNV TPSDVRTLVN GFAKNPLQAR REGLYFKGKDYRCVRADEYS LYAKNENTGV VVVKTHLYLL VATYTEGMYP SICVEATESL GDYLRKKGS.
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: PFN4 profilin family, member 4 [ Homo sapiens ]
• Synonyms: profilin family, member 4; PFN4; profilin-4; profilin IV;Profilin IV
• Gene ID: 375189
• mRNA Refseq: NM_199346
• Protein Refseq: NP_955378
• UniProt ID: profilin IV
• Chromosome Location: 2p23.3
• Pathway: Regulation of actin cytoskeleton
• Function: actin binding