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Recombinant Human Isovaleryl Coenzyme A dehydrogenase, His-tagged

Cat. No. : IVD-1943H
Product Overview : Recombinant human IVD protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques, 45.3 kDa (415aa).
Description : IVD (Isovaleryl Coenzyme A dehydrogenase) is a mitochondrial matrix enzyme that belongs to the acyl-CoA dehydrogenase family. IVD is a homotetrameric flavoenzyme which catalyzes the conversion of isovaleryl-CoA to 3-methylcrotonyl-CoA. Defects of the IVD gene lead to ineffective isoforms that are the underlying cause of isovaleric acidemia.
Source : E.coli.
Purity : > 90% by SDS – PAGE.
Physical Appearance : Liquid.
Formulation : In 20 mM Tris-HCl buffer (pH8.0) containing 1mM DTT, 10% glycerol.
Concentration : 1 mg/ml (determined by Bradford assay).
Sequences Of Amino Acids : MGSSHHHHHH SSGLVPRGSH MHSLLPVDDA INGLSEEQRQ LRQTMAKFLQ EHLAPKAQEI DRSNEFKNLR EFWKQLGNLG VLGITAPVQY GGSGLGYLEH VLVMEEISRA SGAVGLSYGA HSNLCINQLV RNGNEAQKEK YLPKLISGEY IGALAMSEPN AGSDVVSMKL KAEKKGNHYI LNGNKFWITN GPDADVLIVY AKTDLAAVPA SRGITAFIVE KGMPGFSTSK KLDKLGMRGS NTCELIFEDC KIPAANILGH ENKGVYVLMS GLDLERLVLA GGPLGLMQAV LDHTIPYLHV REAFGQKIGH FQLMQGKMAD MYTRLMACRQ YVYNVAKACD EGHCTAKDCA GVILYSAECA TQVALDGIQC FGGNGYINDF PMGRFLRDAK LYEIGAGTSE VRRLVIGRAF NADFH.
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Pathways : Metabolic pathways; Valine, leucine and isoleucine degradation; Metabolism of amino acids and derivatives
Gene Name : IVD isovaleryl Coenzyme A dehydrogenase [ Homo sapiens ]
Synonyms : IVD; isovaleryl Coenzyme A dehydrogenase; ACAD2; FLJ12715; FLJ34849; isovaleryl-CoA dehydrogenase, mitochondrial; EC 1.3.99.10
Gene ID : 3712
mRNA Refseq : NM_001159508
Protein Refseq : NP_001152980
MIM : 607036
UniProt ID : B3KVI7
Chromosome Location : 15q14-q15
Function : FAD binding; isovaleryl-CoA dehydrogenase activity

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