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Recombinant Human Cyclin H, His-tagged

Cat. No.: CCNH-627H
Product Overview: Recombinant human Cyclin H, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. 39.8 kDa (343aa).
Description: Cyclin H, also known as CDK7, is a member of the cyclin-dependent protein kinase family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin H forms a trimeric complex with cyclin H and MAT1, which functions as a CDK-activating kinase (CAK). Cyclin H is an essential component of the transcription factor TFIIH that is involved in transcription initiation and DNA repair.
Source: E.coli.
Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 30% glycerol, 2mM EDTA, 0.1M NaCl.
Purity: > 90% by SDS – PAGE.
Concentration: 1mg/ml (determined by Bradford assay).
Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MYHNSSQKRH WTFSSEEQLA RLRADANRKF RCKAVANGKV LPNDPVFLEP HEEMTLCKYY EKRLLEFCSVFKPAMPRSVV GTACMYFKRF YLNNSVMEYH PRIIMLTCAF LACKVDEFNV SSPQFVGNLR ESPLG QEKAL EQILEYELLL IQQLNFHLIV HNPYRPFEGF LIDLKTRYPI LENPEILRKT ADDFLNRIAL TDAYLLYTPS QIALTAILSS ASRAGITMES YLSESLMLKE NRTC LSQLLDIMKSMRNLVK KYEPPRSEEV AVLKQKLERC HSAELALNVI TKKRK GYEDD DYVSKKSKHE EEEWTDDDLV ESL.
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: CCNH cyclin H [ Homo sapiens ]
Synonyms: CCNH; cyclin H; CAK; p34; p37; CDK-activating kinase; cyclin-dependent kinase-activating kinase; MO15-associated protein; Cyclin-H
Gene ID: 902
mRNA Refseq: NM_001239
Protein Refseq: NP_001230
MIM: 601953
UniProt ID: P51946
Chromosome Location: 5q13.3-q14
Pathway: Cell Cycle, Mitotic; Nucleotide excision repair; DNA Repair; Gene Expression; HIV Infection; Transcription; mRNA Processing
Function: contributes_to RNA polymerase II carboxy-terminal domain kinase activity; contributes_to DNA-dependent ATPase activity; protein binding; contributes_to protein kinase activity

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