"PTP4A3" Related Products


Recombinant Human PTP4A3, 2-173 aa, His-tagged

Cat. No.: PTP4A3-677H
Product Overview: Recombinant human PRL-3 was produced inE. coli.The catalytic domain of PRL-3 (aa 2-173) is fused at the N-terminus to a His-tag. 19.5kDa.
Description: PRL phosphatases comprise a class of small oncogenic phosphatases that are prenylated at their carboxyl-termini. PRL-3 is overexpressed in colon tumors metastasizing to the liver, but not in normal colorectal epithelium. Metastatic lesions have also shown gene amplification of the PRL-3 gene. PRL-3-blocking antibodies reduce metastatic tumor formation by cells overexpressing PRL-3.
Source/Host: E. coli.
Concentration: 0.05μg/μl.
Purity: ≥90% (SDS-PAGE).
Formulation: Liquid. In 25mM TRIS-HCl, pH 8.0, containing 100mM sodium chloride, 0.05% Tween 20, 20% glycerol and 3mM dithiothreitol.
Specific Activity: 0.774U/μg. One unit will hydrolyze 1pmol para-nitrophenyl phosphate (PNPP) per minute at 37°C. Assay buffer: 50mM TRIS, pH 7.4, containing 150mM sodium chloride, 5mM dithiothreitol and 12.5mM PNPP.
Application: Study of enzyme kinetics and regulation, dephosphorylation of target substrates, and inhibitor screening.
Use/Stability: Dilution of the enzyme followed by refreezing may lead to loss of activity.
Long Term Storage: -20°C.
Gene Name: PTP4A3 protein tyrosine phosphatase type IVA, member 3 [ Homo sapiens ]
Synonyms: PTP4A3; protein tyrosine phosphatase type IVA, member 3; PRL3; PRL-3; PRL-R; potentially prenylated protein tyrosine phosphatase; EC
Gene ID: 11156
mRNA Refseq: NM_007079
Protein Refseq: NP_009010
MIM: 606449
UniProt ID: O75365
Chromosome Location: 8q24.3
Function: hydrolase activity; identical protein binding; prenylated protein tyrosine phosphatase activity

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