Recombinant Human CDK4/CCND1, His-tagged
Cat.No. : | CDK4/CCND1-633H |
Product Overview : | Recombinant human CDK4 and Cyclin D1 (amino-acids 16 – 271) Complex of C-terminal His-tagged was Co-expressed in a Baculovirus infectedSf9 cellexpression system. CDK4, MW=34 kDa, Cyclin D1, MW=29 kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : | CDK4/CCND1-633H |
Description : | CDK4 is a member of the cyclin-dependent protein kinase family and is involved in the control of cell proliferation during the G1 phase of cell cycle. CDK4 forms a complex with the D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2). CDK4 can mediate phosphorylation of the C-terminal region of RB protein leading to an active transcriptional repression of E2F complex. CDC37 and HSP90 can preferentially associate with the fraction of CDK4 not bound to D-type cyclins. SMAD3 is a major physiologic substrate of the G1 cyclin-dependent kinases CDK4 and CDK2. |
Source : | Sf9 cells. |
Formulated In : | 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 20% glycerol, and 3 mM DTT. |
Application : | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Stability : | >6 months at –80°C. |
Pathways : | Bladder cancer; Cell cycle; Chronic myeloid leukemia; Glioma; Melanoma; Non-small cell lung cancer; Pancreatic cancer; Pathways in cancer; Small cell lung cancer; T cell receptor signaling pathway; Tight junction; p53 signaling pathway; Cell Cycle, Mitotic; Acute myeloid leukemia; Bladder cancer; Colorectal cancer; Endometrial cancer |
Gene Name : | CDK4 cyclin-dependent kinase 4 [ Homo sapiens ],CCND1 cyclin D1 [ Homo sapiens ] |
Synonyms : | CDK4; cyclin-dependent kinase 4; CMM3; PSK-J3; MGC14458; cell division kinase 4; melanoma cutaneous malignant, 3; EC 2.7.11.22; CCND1; cyclin D1; BCL1; PRAD1; U21B31; D11S287E; cyclin D1 (PRAD1: parathyroid adenomatosis 1); parathyroid adenomatosis 1; B-cell CLL/lymphoma 1; G1/S-specific cyclin D1; G1/S-specific cyclin-D1; PRAD1 oncogene; BCL-1 oncogene |
Gene ID : | 1019,595 |
mRNA Refseq : | NM_000075,NM_053056 |
Protein Refseq : | NP_000066,NP_444284 |
MIM : | 123829,168461 |
UniProt ID : | P11802, P24385 |
Chromosome Location : | 12q14, 11q13 |
Function : | cyclin-dependent protein kinase activity; ATP binding; nucleotide binding; transferase activity; protein complex binding; protein kinase binding |
Products Types
◆ Recombinant Protein | ||
CDK4-962R | Recombinant Rat CDK4 Protein, His (Fc)-Avi-tagged | +Inquiry |
CDK4/CCND3-275H | Recombinant Human CDK4/CCND3, GST-tagged, Active | +Inquiry |
CDK4-1011H | Recombinant Human CDK4 Protein, GST-Tagged | +Inquiry |
CDK4-1525M | Recombinant Mouse CDK4 Protein, His (Fc)-Avi-tagged | +Inquiry |
CDK4-610R | Recombinant Rhesus Macaque CDK4 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
CDK4-664HCL | Recombinant Human CDK4 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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