Active Recombinant Human ARSA, His tagged
Cat.No. : | ARSA-2324H |
Product Overview : | Recombinant Human ARSA (NP_000478.2) (Met 1-Ala 507), fused with a C-terminal polyhistidine tag, was produced in Human Cell. |
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Source : | HEK293 |
Species : | Human |
Tag : | His |
Form : | Lyophilized from sterile 50 mM Tris, pH 8.0. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
Bio-activity : | Measured by its ability to hydrolyze the substrate 4-Nitrocatechol Sulfate (PNCS) . The specific activity is >50 pmoles/min/μg. |
Molecular Mass : | The recombinant human ARSA consists of 500 amino acids and predicts a molecular mass of 53.4 kDa as estimated by SDS-PAGE under reducing conditions. It migrates as an approximately 56.7 kDa band in SDS-PAGE under reducing conditions. |
Protein Length : | Met 1-Ala 507 |
Endotoxin : | < 1.0 EU per μg protein as determined by the LAL method. |
Purity : | > 97 % as determined by SDS-PAGE |
Storage : | Samples are stable for up to twelve months from date of receipt at -20°C to -80°C Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | ARSA arylsulfatase A [ Homo sapiens ] |
Official Symbol : | ARSA |
Synonyms : | ARSA; arylsulfatase A; metachromatic leucodystrophy; ASA; cerebroside-sulfatase; MLD; |
Gene ID : | 410 |
mRNA Refseq : | NM_000487 |
Protein Refseq : | NP_000478 |
MIM : | 607574 |
UniProt ID : | P15289 |
Products Types
◆ Recombinant Protein | ||
ARSA-2826H | Recombinant Human ARSA Protein, MYC/DDK-tagged | +Inquiry |
Arsa-654M | Recombinant Mouse Arsa Protein, MYC/DDK-tagged | +Inquiry |
ARSA-14H | Active Recombinant Human ARSA Protein (21-509), C-His-tagged | +Inquiry |
ARSA-2502H | Recombinant Human ARSA Protein, His (Fc)-Avi-tagged | +Inquiry |
ARSA-533H | Recombinant Human ARSA Protein, His-tagged | +Inquiry |
◆ Lysates | ||
ARSA-3086HCL | Recombinant Human ARSA cell lysate | +Inquiry |
ARSA-3085MCL | Recombinant Mouse ARSA cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (4)
Ask a questionYes, several genetic variations, including point mutations, deletions, and insertions, have been identified in the ARSA gene. These variations can lead to reduced ARSA activity and are responsible for different types and severities of metachromatic leukodystrophy.
At present, there is no cure for metachromatic leukodystrophy caused by ARSA deficiency. However, there are some treatments available that aim to manage the symptoms and slow disease progression, such as enzyme replacement therapy and hematopoietic stem cell transplantation. Research is ongoing to develop more effective therapeutic strategies for this condition.
Deficiency of ARSA activity results in the accumulation of sulfatides within cells, particularly in the central and peripheral nervous systems. This buildup leads to the destruction of myelin, impairing nerve signal transmission and causing the symptoms associated with metachromatic leukodystrophy (MLD), such as motor and cognitive deterioration.
Yes, in addition to MLD, alterations in ARSA activity have been implicated in certain types of multiple sclerosis (MS). Although the exact relationship is not fully understood, it is believed that decreased ARSA function may contribute to the pathogenesis of certain forms of MS.
Customer Reviews (3)
Write a reviewBy utilizing the ARSA protein, I can approach my research with unwavering confidence in its quality, along with the unparalleled support provided by its manufacturer.
I am genuinely excited to embark on this scientific journey, empowered by the superior ARSA protein and the manufacturer's unwavering commitment to ensuring my success.
The ARSA protein comes highly recommended due to its exceptional performance in ELISA assays.
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