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Active Recombinant Human ARSA, His tagged

Cat.No. : ARSA-2324H
Product Overview : Recombinant Human ARSA (NP_000478.2) (Met 1-Ala 507), fused with a C-terminal polyhistidine tag, was produced in Human Cell.
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Source : HEK293
Species : Human
Tag : His
Form : Lyophilized from sterile 50 mM Tris, pH 8.0.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Bio-activity : Measured by its ability to hydrolyze the substrate 4-Nitrocatechol Sulfate (PNCS) . The specific activity is >50 pmoles/min/μg.
Molecular Mass : The recombinant human ARSA consists of 500 amino acids and predicts a molecular mass of 53.4 kDa as estimated by SDS-PAGE under reducing conditions. It migrates as an approximately 56.7 kDa band in SDS-PAGE under reducing conditions.
Protein Length : Met 1-Ala 507
Endotoxin : < 1.0 EU per μg protein as determined by the LAL method.
Purity : > 97 % as determined by SDS-PAGE
Storage : Samples are stable for up to twelve months from date of receipt at -20°C to -80°C
Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : ARSA arylsulfatase A [ Homo sapiens ]
Official Symbol : ARSA
Synonyms : ARSA; arylsulfatase A; metachromatic leucodystrophy; ASA; cerebroside-sulfatase; MLD;
Gene ID : 410
mRNA Refseq : NM_000487
Protein Refseq : NP_000478
MIM : 607574
UniProt ID : P15289

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (4)

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Are there any known genetic variations in the ARSA gene? 06/25/2022

Yes, several genetic variations, including point mutations, deletions, and insertions, have been identified in the ARSA gene. These variations can lead to reduced ARSA activity and are responsible for different types and severities of metachromatic leukodystrophy.

Can ARSA deficiency be treated? 11/21/2018

At present, there is no cure for metachromatic leukodystrophy caused by ARSA deficiency. However, there are some treatments available that aim to manage the symptoms and slow disease progression, such as enzyme replacement therapy and hematopoietic stem cell transplantation. Research is ongoing to develop more effective therapeutic strategies for this condition.

What happens if ARSA is deficient? 12/01/2016

Deficiency of ARSA activity results in the accumulation of sulfatides within cells, particularly in the central and peripheral nervous systems. This buildup leads to the destruction of myelin, impairing nerve signal transmission and causing the symptoms associated with metachromatic leukodystrophy (MLD), such as motor and cognitive deterioration.

Is ARSA protein associated with any other diseases besides metachromatic leukodystrophy? 03/13/2016

Yes, in addition to MLD, alterations in ARSA activity have been implicated in certain types of multiple sclerosis (MS). Although the exact relationship is not fully understood, it is believed that decreased ARSA function may contribute to the pathogenesis of certain forms of MS.

Customer Reviews (3)

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Reviews
12/20/2021

    By utilizing the ARSA protein, I can approach my research with unwavering confidence in its quality, along with the unparalleled support provided by its manufacturer.

    03/05/2020

      I am genuinely excited to embark on this scientific journey, empowered by the superior ARSA protein and the manufacturer's unwavering commitment to ensuring my success.

      10/01/2017

        The ARSA protein comes highly recommended due to its exceptional performance in ELISA assays.

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