"METAP2" Related Products

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Recombinant Human METAP2 protein, HA-tagged

Cat.No.: METAP2-630H
Product Overview: Recombinant Human METAP2(aa 1-478) fused with hemagglutinin (HA) tag (YPYDVPDYA) at N-terminal was expressed in Insect cells.
Description: MetAP2 is a metalloenzyme that catalyzes removal of the N-terminal methionine from proteins, with the physiologically relevant metal thought to be either cobalt or manganese. Since it was identified as the target of the anti-angiogenic natural product fumagilin (Prod. No. BML-CT100), it has been studied for its involvement in cancer, angiogenesis, inflammation, and rheumatoid arthritis. Because of differing substrate specificities and kinetics it is not desirable to substitute bacterial methionine aminopeptidase for mammalian MetAP2.
Source: Insect cells
Species: Human
Tag: HA
Form: Liquid. In 20mM HEPES, pH 7.3, containing 150mM sodium chloride, 10% glycerol, 0.02% sodium azide, and 0.1mM CoCl2.
Molecular Mass: ~70kDa
Purity: ≥95% (SDS-PAGE)
Stability: Stable for at least 6 months after receipt when stored at -80 centigrade.
Storage: Long Term Storage: -80 centigrade; Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80 centigrade.
Gene Name: METAP2 methionyl aminopeptidase 2 [ Homo sapiens ]
Official Symbol: METAP2
Synonyms: METAP2; methionyl aminopeptidase 2; methionine aminopeptidase 2; MAP2; MNPEP; p67; Peptidase M; MAP 2; metAP 2; peptidase M 2; eIF-2-associated p67 homolog; initiation factor 2-associated 67 kDa glycoprotein; p67eIF2;
Gene ID: 10988
mRNA Refseq: NM_006838
Protein Refseq: NP_006829
MIM: 601870
UniProt ID: P50579
Chromosome Location: 12q22
Function: aminopeptidase activity; metal ion binding; metalloexopeptidase activity; peptidase activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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