Recombinant Human DUSP6 DUSP6-631H

Recombinant Human DUSP6

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Recombinant Human DUSP6

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Cat. No. : DUSP6-631H
Product Overview : Recombinant Human DUSP6 isproduced inSf9 cells.MW=42 kDa / 41 kDa.
Description : The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.
Source : Sf9 cells.
Storage : -80°C.
PDB rendering based on 1hzm. :

Publication :
Gene Name : DUSP6 dual specificity phosphatase 6 [ Homo sapiens ]
Synonyms : DUSP6; dual specificity phosphatase 6; MKP3; PYST1; MAP kinase phosphatase 3; dual specificity protein phosphatase 6; dual specificity protein phosphatase PYST1; mitogen-activated protein kinase phosphatase 3; serine/threonine specific protein phosphatase; EC 3.1.3.48; EC 3.1.3.16
Gene ID : 1848
mRNA Refseq : NM_001946
Protein Refseq : NP_001937
MIM : 602748
UniProt ID : Q16828
Chromosome Location : 12q22-q23
Pathway : MAPK signaling pathway; Signaling in Immune system; Signalling by NGF
Function : MAP kinase tyrosine/serine/threonine phosphatase ; hydrolase activity; protein binding; protein tyrosine phosphatase activity

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