"HFE2" Related Products


Recombinant Human Hemochromatosis Type 2 (Juvenile), FLAG-tagged

Cat. No.: HFE2-2419H
Product Overview: Recombinant Human RGMC (aa 36-398) produced in HEK 293 cells is fused at the N-terminus to a linker peptide (8 aa) and a FLAG-tag.
Description: The RGMC (also called Hemojuvelin) is an GPI-anchored protein involved in the iron metabolism through regulation of hepcidin expression. Mutations in the gene encoding RGMC cause severe iron overload (juvenile hemochromatosis /hemochromatosis type 2A). The protein binds to neogenin and acts as co-receptor of the bone morphogenetic protein. The mature RGMc protein is proteolytically processed and glycosylated.
Source/Host: HEK 293 cells.
Concentration: 0.1mg/ml after reconstitution.
Purity: ≥95% (SDS-PAGE).
Endotoxin Content: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
Reconstitution: Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
Short Term Storage: -20°C.
Formulation: Lyophilized. Contains PBS.
Long Term Storage: -20°C.
Use/Stability: Stable for at least 6 months after receipt when stored at -20°C.
Handling: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Gene Name: HFE2 hemochromatosis type 2 (juvenile) [ Homo sapiens ]
Synonyms: hemochromatosis type 2 (juvenile); JH; HJV; RGMC; HFE2A; MGC23953; HFE2; hemojuvelin; haemojuvelin; RGM domain family member C; hemochromatosis type 2 protein; Hemochromatosis type 2 protein; RGM domain family, member C; LEAP1; HAMP; HEPC
Gene ID: 148738
mRNA Refseq: NM_145277
Protein Refseq: NP_660320
MIM: 608374
UniProt ID: Q6ZVN8
Chromosome Location: 1q21.1

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.