"HFE2" Related Products


Recombinant Human Hemochromatosis Type 2 (Juvenile), FLAG-tagged

Cat. No. : HFE2-2419H
Product Overview : Recombinant Human RGMC (aa 36-398) produced in HEK 293 cells is fused at the N-terminus to a linker peptide (8 aa) and a FLAG-tag.
Description : The RGMC (also called Hemojuvelin) is an GPI-anchored protein involved in the iron metabolism through regulation of hepcidin expression. Mutations in the gene encoding RGMC cause severe iron overload (juvenile hemochromatosis /hemochromatosis type 2A). The protein binds to neogenin and acts as co-receptor of the bone morphogenetic protein. The mature RGMc protein is proteolytically processed and glycosylated.
Source/Host : HEK 293 cells.
Concentration : 0.1mg/ml after reconstitution.
Purity : ≥95% (SDS-PAGE).
Endotoxin Content : <0.1EU/µg purified protein (LAL test; Bio Whittaker).
Reconstitution : Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
Short Term Storage : -20°C.
Formulation : Lyophilized. Contains PBS.
Long Term Storage : -20°C.
Use/Stability : Stable for at least 6 months after receipt when stored at -20°C.
Handling : After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Gene Name : HFE2 hemochromatosis type 2 (juvenile) [ Homo sapiens ]
Synonyms : hemochromatosis type 2 (juvenile); JH; HJV; RGMC; HFE2A; MGC23953; HFE2; hemojuvelin; haemojuvelin; RGM domain family member C; hemochromatosis type 2 protein; Hemochromatosis type 2 protein; RGM domain family, member C; LEAP1; HAMP; HEPC
Gene ID : 148738
mRNA Refseq : NM_145277
Protein Refseq : NP_660320
MIM : 608374
UniProt ID : Q6ZVN8
Chromosome Location : 1q21.1

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